多形性肉芽肿

Granuloma multiforme

报告1例多形性肉芽肿。患者男,52岁。躯干上部及上肢环状质硬斑块10年。皮肤科检查:颈部、胸部见粟米大坚实丘疹,融合成环形或地图状。皮损表面无鳞屑,未见溃疡或瘢痕。双手背、前臂见数个类似皮损。皮损组织病理检查示真皮浅、中层见局灶性渐进性坏死及明显栅栏状肉芽肿,可见较多多核巨细胞。诊断为多形性肉芽肿。

A 52-year old male presented 10 years history of indurated annular lesions on the upper trunk and limbs. Dermatological examination revealed 2-3 mm sized, nontender papules or nodules on the neck and upper trunk. The lesions tended to be annular and figurate coalescence. There were no scales, ulcerations or scars. Similar lesions were observed on both dorsum hands and fore- arms. In the superficial and middle dermis, loci degeneration of the collagen bundles and palisading granulomas were seen. Moderate multinucleated giant cell was another pathological finding. A diagnosis of granuloma muhiforme was finally made.