牙周感染对血管内皮功能影响的研究

The effects of periodontal infection on vascular endothelial function

目的:探讨中、重度牙周炎对血管内皮功能的影响。方法:用血管超声测定36例中、重度牙周炎病人、30例健康人血流介导的肱动脉扩张和硝酸甘油介导的肱动脉扩张,并使两组的性别和年龄匹配,排除高血压、糖尿病、高血脂和有吸烟史的病人。结果:牙周炎组血流介导的肱动脉扩张(6.91±3.12)%比正常对照组(13.66±5.01)%明显减弱(P<0.05)。牙周炎组硝酸甘油介导的肱动脉扩张(16.55±8.63)%与正常对照组(17.26±8.81)%比较差异无统计学意义(P>0.05)。结论:牙周感染会影响血管内皮功能,增加动脉粥样硬化的风险。

AIM： To investigate the effect of moderate to severe periodontitis on vascular endothelial function. METHODS： We assessed flow mediated dilation and nitroglycerin mediated dilation of the brachial artery using vascular ultrasound in 36 subjects with moderate to severe periodontitis and 30 control subjects. The groups were matched for age and sex. Patients with hypercholesterolemia, diabetes mellitus, hypertension, and history of cigarette smoking were excluded from the study. RESULTS： As compared with that in the control group, flow mediated brachial artery dilation in periodontitis group was significantly decreased （6. 91 _＋ 3. 12 ）% in periodontitis group versus （13.66 -＋ 5.01 ）% in control group（ P 〈 0.05 ）. However there was no significant difference in nitroglycerin mediated brachial artery dilation between two groups （ 16.55 ± 8.63 ） % in periodontitis group versus （ 17.26 ± 8.81 ） % in the control group （P 〉 0.05）. CONCLUSION ： Periodontal infection can affect vascular endothelial function and may increase the risk of coronary heart disease.