期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

依曲替酸对银屑病患者皮损区IL-17表达的影响 被引量：3

The Effect of Acitretin on Expresion of IL-17 in Lesions of Psoriatic Patients
下载PDF
导出
摘要 目的探讨依曲替酸对中、重度银屑病患者皮损区白介素(IL)-17表达的影响。方法观察依曲替酸的临床疗效;用原位杂交技术及蛋白印迹法(Westernblot)检测患者治疗前、后皮损区IL-17mRNA和IL-17蛋白表达。结果依曲替酸在改善患者病情的同时,抑制了皮损区IL-17mRNA的表达(治疗前39.95±11.44,治疗后16.20±6.65)及蛋白表达(治疗前0.85±0.10,治疗后0.26±0.10),差异均有统计学意义(P均<0.05)。结论依曲替酸治疗银屑病的作用可能涉及对患者皮肤Th17细胞的影响。 Objective To investigate the effect of acitretin on expression of lnterleukin （IL）-17 in lesions of psoriatic patients. Methods The clinical effects of acitretin on psoriatic patients were observed. The mRNA and protein of IL-17 in lesions before and after the treatment were measured by hybridization in situ and western blot. Results The patient＇s condition improved greatly after aeitretin treatment. The level of IL-17mRNA （ prior treatment 39.95 ± 11.44,post-treatment 16.20±6.65 ） and IL-17 protein （ prior treatment 0.85± 0.10,post-treatment 0.26 ± 0.10） （ all P 〈 0.05） decreased significantly. Conclusion Thl7 cells may be involved in the effect of aeitretin in treating psoriatic patients.
作者 牛新武 曹伟 冯捷 彭振辉 袁景奕
机构地区 西安交通大学医学院第二附属医院皮肤科
出处 《中国皮肤性病学杂志》 CAS 北大核心 2010年第7期613-615,共3页 The Chinese Journal of Dermatovenereology
基金 教育部博士点基金新教师项目(编号:20070698071) 陕西省科学技术研究发展计划项目(编号:2008K15-06(14))
关键词 银屑病 寻常性 依曲替酸 Th17细胞 白介素-17 Psoriasis, vulgaris Acitretin Th17 cell Interleukin-17
分类号 R758.63 [医药卫生—皮肤病学与性病学]
  • 相关文献

参考文献9

  • 1Chen Z,Laurence A,O'Shea JJ.Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation[J].Semin Immunol,2007,19 (6):400-408.
  • 2彭振辉,牛新武.维A酸类药物与皮肤病[J].中国皮肤性病学杂志,2004,18(6):374-378. 被引量：60
  • 3李小红,于建斌,张江安.复方氟米松软膏治疗寻常性银屑病临床观察[J].中国皮肤性病学杂志,2008,22(8):509-510. 被引量：8
  • 4Alexandra R,Seth J.Oral retinoid therapy for dermatologic conditions in children and adolescents[J].J AM ACAD Dermatol,2003,49 (2):171-182.
  • 5Ghoreschi K,Weigert C,Rocken M.Immunopathogenesis and role of T cells in psoriasis[J].Clin Dermatol,2007,25(6):574-580.
  • 6Lowes MA,Kikuchi T,Fuentes-Duculan J,et al.Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells[J].J Invest Dermatol,2008,128 (5):1064-1067.
  • 7Komiyama Y,Nakae S,Matsuki T,et al.IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis[J].J Immunol,2006,177 (1):566-573.
  • 8Klemann C,Raveney BJ,Klemann AK,et al.Synthetic retinoid AM80 inhibits Th17 cells and ameliorates experimental autoimmune encephalomyelitis[J].Am J Pathol,2009,174 (6):2234-2245.
  • 9刘俐伶,麻继臣.阿维A胶囊治疗寻常型银屑病34例疗效观察[J].中国麻风皮肤病杂志,2006,22(10):868-869. 被引量：9

二级参考文献12

  • 1Dawson MI,Park JH,Chen G,et al. Retinoic acid(RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC)activity by retinoids: a potential role for trans-RA-induced ZBP-
  • 2Xu Feng, Zhen-Hui Peng, Wei Di, et al. Suprbasal expression of a dominant-negative RXR-alpha mutant in transgenic mouse epider mis impairs regulation of gene transcription and basal kerstinocyte proliferation by RAR-selective retinouds[J]. GENES&amp;DECEL
  • 3Makoto Iwata, Yuko Eshima, Hiroyuki Kagechika, et al. Retinoic acids exert direct effects or T cells to suppress Thl development and enhance Th2 development via retinoic acid receptors[J]. International Immunology, 2003,15 (8): 1017- 1025.
  • 4Mohamad Mohty, Silvia Morbelli, Daniel Isnardon, et al. All-trans retinoic acid skews monocyte differentiationinto interleukin-12-secreting dendritic-like cells[J]. British Journal of Haematology Vol ume, 2003,122(5): 829.
  • 5Reichrath J, Mittmann M, Kamradt J,et al. Expression of retinoid X receptors(alpha, beta, gamma) and retinoic acid receptors (alpha, beta, gamma) in normal human skin: an immunohistologicalevaluation[J]. Histochem J ,1997,29(2): 127-33.
  • 6Torma H, Karlsson T,Michaelsson G,et al. Decreased mRNA levels of retinoic acid receptor alpha, retinoid X receptor alpha and thyroid hormone receptor alpha in lesional psoriatic skin[J]. Acta Derm Venereol,2000,80(1) :4-9.
  • 7Boudjelal M, Wang Z, Voorhees JJ, et al. Ubiquitin/proteasome pathway regulates levels of retinoic acid receptor gamma and retinoid X receptor alpha in human keratinocytes[J]. Cancer res, 2000 , 60(8): 2247- 52.
  • 8Xu XC, Wong WY, Goldberg L,et al. Progressive decreases in nuclear retinoid receptors during skin squamous carcinogenesis [J]. Cancer Rra,2001, 61(11) :4306-10.
  • 9赵辩.临床皮肤性病学[M](第3版)[M].南京:江苏科学技术出版社,2001..
  • 10CARROLL CL, CLARK J, CAMACHO F, et al. Topical tacrolimus ointment combined with 6% salicylic acid gel for plaque psoriasis treatment[ J]. Arch Dermatol, 2005,141 (1) :43 -46.

共引文献72

同被引文献37

  • 1吴勤学,张良芬,陈小红,尹跃平,余艳华,李志诚,郁华,史月君,吕成志,林钧伦,冯素英,李晓杰.用ND-ELISA检测已治愈的麻风患者血中IgM抗体水平[J].中华皮肤科杂志,2004,37(9):537-539. 被引量：2
  • 2钱起丰,卢创林,张明霞.复发性生殖器疱疹患者外周血CD4^+CD25^+Foxp3^+调节性T细胞的检测[J].中华皮肤科杂志,2006,39(12):695-698. 被引量：11
  • 3Alcais A, Alter A, Antoni G, et al. Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for earlyonset leprosy[J]. Nat, 2007,39(4):517 -522.
  • 4Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4^+ CD25^+ regulatory T cells[J]. Nat Immunol, 2003, 4(4) :330 -336.
  • 5Zheng SG, Wang JH, Stohl W, et al. TGF-beta requires CTLA-4 early after T cell activation to induce Foxp3 and generate adaptive CD4^+ CD25^+ regulatory cells[J]. J Immunol, 2006, 176(6) :3321 -3329.
  • 6Sakaguchi S, Ono M, Setoguchi R, et al. Foxp3^+ CD25^+ CD4^+ natural regulatory T cells in dominant self-tolerance and autoimmune disease [J]. Immunol Rev, 2006,6(3) :2127 -2128.
  • 7Kim JM, Rudensky A. The role of the transcription factor Foxp3 in the development of regulatory T cells[ J]. Immunol Rev, 2006,9( 8 ) :86 - 98.
  • 8Chen TC, Cobbold SP, Fairchild PJ, et al. Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen [ J]. Immunol, 2004, 172 (10) :5900 - 5907.
  • 9Mushy KM, Reiner SL. The lineage decisions of helper T cells [ J ]. Nat Rev Immunol,2002,2(12) :933 -944.
  • 10Veldhoen M,Hocking RJ,Atkins CJ,et al. TGF beta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL- 17-producing T cells [ J ]. Immunity,2006,24 ( 2 ) : 179 - 189.

引证文献3

二级引证文献30

中国皮肤性病学杂志
2010年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部