骨组织工程相关研究新进展

NEW PROGRESS OF RELATED RESEARCH OF BONE TISSUE ENGINEERING

目的对近年来骨组织工程相关研究的新进展进行综述。方法查阅近年来国内外骨组织工程研究的相关文献,总结其最新进展。结果近年来,骨组织工程取得了长足进步,多家单位已成功将其应用于临床,国家卫生部也制订了相关管理规范。在种子细胞领域,多采用自体成体干细胞和异体细胞,胚胎干细胞及自体体细胞来源的诱导多能干细胞成为目前的研究热点。支架材料方面,由天然提取成分构建的材料发展为人工合成的高分子材料;由单一的支架材料发展成复合材料、表面修饰材料。在组织构建方面,既往多采用细胞悬液滴入支架材料的静置接种法,生物反应器为细胞组织的体外培养提供了稳定的微环境,可满足不同组织培养所需的条件,为组织构建和体外培养提供了新选择。结论以上进步推动了骨组织工程的快速发展,不久的将来有望研制出一系列组织工程骨医疗产品造福于广大患者。

Objective To review new progress of related research of bone tissue engineering in recent years.Methods Domestic and international literature concerning bone tissue engineering was reviewed and analyzed.Results In the recent years,great progression had been made in the research and development of bone tissue engineering,it had been used in more and more hospitals,and relevant national regulations and protocols had been set up.As to seed cells of bone tissue engineering,autologous and allogeneic stem cells had been widely used,while recently embryonic stem cells and induced pluripotent stem cells had attracted most attentions.In the field of scaffolds materials,significant improvements had been made,from natural extractions to artificial polymers;from single construction to multiple compounds with surface modifications.As to the methods of construction,the static seeding approach had been widely accepted,and the applications of bioreactor had provided a stable and various micro-enviroment for the vitro-culture of different stem cells,which had been regarded as an alternative way of vitro-culture and construction for bone tissue engineering.Conclusion With the tremendous help of the techniques and approaches above,we shall expect a promising future of a new generation bone tissue engineering based medical products in the years to come.