X染色体连锁的凋亡抑制蛋白和Caspase-3在上皮性卵巢癌中的表达及其临床意义

Expression and clinical significance of Xiap and Caspase-3 protein in primary epithelia ovarian cancer

目的：探讨x染色体连锁的凋亡抑制蛋白（Xiap）和Caspase-3在上皮性卵巢癌中的表达变化及其临床意义。方法：采用免疫组织化学两步法检测Xiap和Caspase-3在40例上皮性卵巢癌、20例卵巢上皮性交界性肿瘤、15例卵巢良性肿瘤和15例正常卵巢组织中的表达。结果：Xiap在正常卵巢组织、良性卵巢肿瘤、交界性卵巢肿瘤组织和上皮性卵巢癌中的阳性表达率呈逐渐增高趋势，差异有统计学意义（P〈0．01）。Caspase-3在交界性卵巢肿瘤和上皮性卵巢癌中的阳性表达率明显低于正常卵巢组织和良性卵巢肿瘤（P〈0．01）。上皮性卵巢癌中Xiap的阳性表达与临床分期、组织分级和生存状况有关（P〈0．01）；Caspase-3的阳性表达与临床分期和生存状况有关（P〈0．01）。结论：XIAP、Caspase-3的表达在上皮性卵巢癌的发生、发展过程中起重要作用，可能是上皮性卵巢癌预后不良的因素。

AIM： To study the expression and clinical significance of Xiap, Caspase-3 protein in primary epithelia ovarian cancer. METHODS： The Xiap and Caspase-3 were detected by immunohistochemical in 40 cases of epithelial ovarian caner 20 cases of borderline ovarian tumor, 15 cases of benign ovarian tumor, and 15 normal ovarian tissues. RESULTS： There were significantly different between the expression of Xiap in epithelial ovarian caner, borderline ovarian tumor, benign ovarian tumor and normal ovarian tissues. The expression of Caspase-3 in epithelial ovarian cancer and borderline ovarian tumor was significantly lower than that in benign ovarian tumor and normal ovarian tissue （P 〈 0.0l ）. The expression of Xiap in epithelial ovarian cancer was relate to clinc stage, pathological grade and living. The expression of caspase-3 in epithelial ovarian cancer was relate to clinc stage and living （ P 〈 0.01 ）. CONCLUSION： The expressions of Xiap and Caspase-3 may be important roles for the formation and development of epithelia ovarian cancer. The expressions of Xiap and Caspase-3 are the poor prognostic factors in epithelial ovarian carcinomas.