摘要
Ribozyme和DNAzyme具有水解mRNA分子的功能,是阻断基因表达和抗病毒的重要工具。近年来,Ribozyme和DNAzyme在临床治疗研究中已经获得了长足进展,有许多成功的实例。比较了Ribozyme和DNAzyme的差异和特点,总结了它们在抗病毒、抗肿瘤、治疗遗传病、治疗神经系统疾病等方面的临床前研究、应用及进展。
Ribozymes and DNAzymes have a function of hydrolysis to mRNA molecules.They have become important tools for blocking gene expression and anti-virus.In recent years,Ribozymes and DNAzymes have been used in inclinical studies,and there have got many successful examples.The differences and characteristics between Ribozyme and DNAzyme were compared,and the progress in anti-virus,anti-cancer,treatment of genetic diseases,treatment of nervous system diseases in pre-clinical researches were summarised.It was supposed to give a prospective remarks.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2010年第6期122-129,共8页
China Biotechnology
基金
国家科技重大专项(2008ZXJ09001-014)资助项目
