2型糖尿病幽门螺杆菌感染情况分析

Analysis of Helicobacter pylori infection status in type 2 diabetes mellitus

目的 了解2型糖尿病（T2DM）患者幽门螺杆菌（Hp）感染情况,初步探讨Hp与T2DM的关系.方法 768例住院T2DM患者[T2DM组,其中新诊断T2DM 194例（新诊组）,再诊断T2DM 574例（再诊组）]及健康查体者172例（对照组）行14C尿素呼气试验,分别比较T2DM组和对照组间总Hp感染率、不同性别间Hp感染率;新诊组及再诊组间总Hp感染率;不同年龄段T2DM组患者不同性别间Hp感染率.结果 T2DM组总Hp感染率高于对照组[56.0%（430/768）比37.8%（65/172）,P〈0.01],T2DM组与对照组同性别Hp感染率比较差异均有统计学意义（P〈0.01）.新诊组与再诊组间总Hp感染率、不同性别间Hp感染率比较差异无统计学意义（P〉0.05）.不同年龄段T2DM组患者不同性别间Hp感染率比较差异无统计学意义（P〉0.05）.结论 T2DM患者Hp感染率高于非糖尿病者,Hp感染与T2DM有密切关系,与患者年龄、性别、病程无关.

Objective To comprehend the status of Helicobacter pylori （Hp） infection in type 2 diabetes mellitus （T2DM） patients, and study the relationship between Hp and T2DM. Methods Seven hundred and sixty-eight in-hospital T2DM patients （T2DM group, including new diagnosed 194 patients and re-diagnosed 574 patients） and 172 sex, age matched health individuals（control group ） were involved in this study. 14C-urea breath test （14C-UBT） was proceeded in both groups to determine Hp infection, and infection rates were calculated. Results Total Hp infection rate in T2DM group was significantly higher than that in control group [56.0%（430/768） vs 37.8%（65/172） ,P〈 0.01], delamination analysis according to sex also showed significant differences between T2DM group and control group（P 〈 0.01）. The rate of Hp infection in new diagnosed patients and re-diagnosed patients, female patients and male patients had no significant difference （P 〉 0.05 ）. The rate of Hp infection in different age and sex had no significant difference （P 〉0.05 ）. Conclusions The rate of Hp infection in T2DM patients is higher than that in non-T2DM patients.Hp infection has relationship with T2DM, and has no relationship with age, sex and course of disease.