丁胱亚磺酰亚胺对Acc-2移植瘤放射增敏的实验研究

Experimental study of radiosensitization of buthionine sulfoximine(BSO)on Acc 2 transplanted tumor

目的在体内研究放射增敏剂丁胱亚磺酰亚胺（ｂｕｔｈｉｏｎｉｎｅｓｕｌｆｏｘｉｍｉｎｅ，ＢＳＯ）对Ａｃｃ－２移植瘤的放射增敏作用。方法以Ａｃｃ－２移植瘤为模型，实验设对照组、ＢＳＯ组、单放组和ＢＳＯ＋放射组。ＢＳＯ药物剂量为５ｍｍｏｌ／ｋｇ，放射剂量为１０Ｇｙ。结果各组与对照组比较，ＢＳＯ组抑瘤率为８．５％、单放组为１２．６％，ＢＳＯ＋放射组为４５．３７％。结论ＢＳＯ对Ａｃｃ－２移植瘤有放射增敏作用。

Objective The effect of radiosensitization of BSO on Acc 2 transplanted tumor was studied in vivo.Methods There were four groups in this experiment:control group、BSO group、radiation group and BSO+radiation group.The drug dose of BSO is 5mmol/kg and the radiation dose was 10Gy. Results The result demonstrated that the tumor inhibitive rate was 8.5%、12.6% and 45.37% respectivly compared with control group.Conclusion BSO has radiosensitizative effect on Acc 2 transplanted tumor.