干燥综合征动物模型的建立及中药疗效的观察

Exprimental research on animal model and treatment of Sjgrens syndrome by traditional chinese medicine(TCM)

目的进一步确立干燥综合征（ＳＳ）的动物模型并观察中药制剂ＳＳ糖浆治疗干燥综合征的疗效。方法采用利血平＋甲状腺素造型法的气阴二虚证动物模型，应用ＳＳ糖浆进行疗效的观察。结果ＳＳ糖浆治疗组各项观察指标有明显改善，动物体重增加情况、饮水量及ｃＡＭＰ值均接近正常对照组（Ｐ＞０．０５）。而实验对照组和治疗对照组无明显变化（Ｐ＜０．０５）。结论进一步明确了ＳＳ糖浆具有一定的健脾益气，滋阴润燥功能。

Objective To confirm the function of SS Syrup used in our department. Methods Under the basis of TCM and differentiation symptoms of SS,the animal model was established and applied to test the function of SS syrup.There are three indices to be observed,weight change,volume of drinking water daily,cAMP change. Results The three observed indices of deficiency symptom model had been rectified by SS syrup. Conclusion SS syrup has two main functions:(1)reinforcing of the spleen and tonifying qi;(2)nourishing liver yin and kidney yin as well as removing pathogenic heat and fire.