内源性大麻素系统与阻塞性睡眠呼吸暂停合并症

Endocannabinoid system and complications of obstructive sleep apnea

阻塞性睡眠呼吸暂停（obstructive sleep apnea,OSA）是以睡眠过程中反复的上气道狭窄甚至完全闭塞导致频繁发生呼吸暂停为特征的睡眠呼吸障碍性疾病,该疾病与白天嗜睡、肥胖、高血压、缺血性心脏病、心律失常等均有明显的相关性.内源性大麻素系统（endocannabinoid system,ECS）是新近发现的信号系统,由内源性大麻素（endogenous cannabinoids,EC）,大麻素受体CB1、CB2及合成、降解EC的酶类共同组成.在体内,ECS有广泛的生理学作用.

Obstructive sleep apnea, a common breathing-related sleep disorder, characterized by frequents of apnea lasting seconds to minutes during sleep as a result of airway obstruction,is associated with daytime sleepiness,obesity,hypertension,coronary heart disease,cardiac arrhythmia and so on. The endocannabinoid system is a new endogenous signaling system, which is composed of cannabinoid receptors,endocannabinoids and the molecular machinery required for their synthesis and degradation,and body,the endocannabinoid system is involved in many physiological functions.