降钙素原联合C-反应蛋白检测对新生儿败血症的临床诊断价值

Serum Procalcitonin and C Reactive Protein in Diagnosis of Neonatal Sepsis Patients

目的:探讨血清降钙素原(PCT)联合C反应蛋白(CRP)检测对新生儿败血症诊断的临床价值。方法:化学发光免疫法测定血浆PCT含量和散射比浊法测定血浆CRP水平。结果:败血症患儿中PCT(78.85±19.16ng/mL)和CRP(53.17±35.68mg/L)水平明显高于正常对照组(0.35±0.13ng/mL和5.87±3.77mg/L),差异有统计学意义(P<0.01);PCT的特异性、阳性预测值、准确性性和约登指数高于CRP。PCT和CRP水平与患儿病情的严重程度呈正相关。结论:血清PCT联合CRP测定可为新生儿败血症诊断提供更准确的诊断依据。

Objective：To evaluate the clinical significance of the detection of serum procalcitonin（PCT）and C reactive protein（CRP） in the diagnosis of neonatal sepsis.Method： PCT was determined by chemiluminescence immunoassay and CRP was measured by nephelometry.Result： The serum level of PCT and CRP in the neonatal sepsis group was（78.85±19.16）ng/mL and（53.17±35.68）mg/L respectively,which were much higher than those in the control group（0.35±0.13）ng/mL and（5.87±3.77）mg/L respectively（P 0.01）.PCT and CRP had higher specificity,positive predictive value,accuracy and youden index.The levels of PCT and CRP were positively correlated to the severity of the illness.Conclusion： Concurrent determination of serum PCT and CRP could provide more accurate diagnostic evidence neonatal sepsis patients.