摘要
目的:探讨血清降钙素原(PCT)联合C反应蛋白(CRP)检测对新生儿败血症诊断的临床价值。方法:化学发光免疫法测定血浆PCT含量和散射比浊法测定血浆CRP水平。结果:败血症患儿中PCT(78.85±19.16ng/mL)和CRP(53.17±35.68mg/L)水平明显高于正常对照组(0.35±0.13ng/mL和5.87±3.77mg/L),差异有统计学意义(P<0.01);PCT的特异性、阳性预测值、准确性性和约登指数高于CRP。PCT和CRP水平与患儿病情的严重程度呈正相关。结论:血清PCT联合CRP测定可为新生儿败血症诊断提供更准确的诊断依据。
Objective:To evaluate the clinical significance of the detection of serum procalcitonin(PCT)and C reactive protein(CRP) in the diagnosis of neonatal sepsis.Method: PCT was determined by chemiluminescence immunoassay and CRP was measured by nephelometry.Result: The serum level of PCT and CRP in the neonatal sepsis group was(78.85±19.16)ng/mL and(53.17±35.68)mg/L respectively,which were much higher than those in the control group(0.35±0.13)ng/mL and(5.87±3.77)mg/L respectively(P 0.01).PCT and CRP had higher specificity,positive predictive value,accuracy and youden index.The levels of PCT and CRP were positively correlated to the severity of the illness.Conclusion: Concurrent determination of serum PCT and CRP could provide more accurate diagnostic evidence neonatal sepsis patients.
出处
《河北医学》
CAS
2010年第7期791-793,共3页
Hebei Medicine
关键词
降钙素原
C反应蛋白
败血症
Procalcitonin(PCT)
C-reactive protein
Neonatal sepsis