血必净注射液联合生长抑素对轻症急性胰腺炎细胞因子的影响

Effect of Xuebijing Injection Combined with Somatostatin on the Cytokine in Mild Acute Pancreatitis

目的:观察血必净注射液联合生长抑素对轻症急性胰腺炎(SAP)血清肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)的影响。方法:将60例SAP患者随机分为治疗组和对照组,治疗组在西医综合治疗基础上加用血必净注射液,对照组仅采用西医综合治疗。检测治疗前及治疗后1、3、7d两组患者血清TNF-α、IL-10水平。结果:治疗前及治疗后1d,两组患者TNF-α、IL-10水平差异均无统计学意义(P>0.05),但在治疗后3、7d,治疗组患者血清TNF-α水平较对照组患者显著下降(P<O.05),而IL-10水平较对照组患者显著升高(P<0.O5)。结论:血必净注射液能抑制TNF-α分泌,上调IL-10水平,改善炎性细胞因子平衡,对急性胰腺炎具有良好的治疗作用。

Objective：To investigate the effect of Xuebijing injection combined with somatostatin on the cytokine in mild acute pancreatitis（MAP）.Method： 60 patients with MAP were randomly divided into two groups.Therapeutic group were treated by routine treatment and Xuebijin injection,control group were routinely performed only.Serum TNF-α and IL-10 were determined before and 1、3、7 days after therapy by radiommunoassay.Result：There were no significant changes in serum TNF-α and IL-10 between two groups on the first day after treatment（P0.05）.The serum levels of TNF-α of MAP were significantly decreased in the therapeutic group than those in the control group on third and seventh day after the use of Xuebijing injection（P0.05）.But the serum levels of IL-10 of MAP were significantly higher in the therapeutic group than those in the control group（P0.05）.Conclusion： Xuebijing injection has therapeutic effects on MAP by inhabiting serum TNF-α level and increasing IL-10 level.