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2型糖尿病患者呼气冷凝液中总硝酸盐的变化

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摘要 目的观察2型糖尿病患者呼气冷凝液(exhaled breath condansate,EBC)中总硝酸盐(一氧化氮代谢物)的改变,为诊断2型糖尿病肺损害提供新方法。方法本实验选择16例2型糖尿病患者和20例健康非吸烟者;用Rtube收集器收集EBC,用分光光度法检测EBC中总硝酸盐(nitrite/nitrate,NO2-/NO3-),同时检测并记录肺功能。结果 2型糖尿病患者呼出气冷凝液总NO2-/NO3-水平增高(P<0.05);2型糖尿病与对照组之间肺功能FEV1%预计值比较有统计学意义(P<0.05)、肺弥散(DLCO)%预计值与对照组之间比较有统计学意义(P<0.01)。结论总NO2-/NO3-在2型糖尿病肺损害的发病中起重要作用,对不同时期2型糖尿病EBC中的NO2-、NO2-/NO3-的水平变化,尚需进一步研究。
出处 《河北医药》 CAS 2010年第13期1725-1726,共2页 Hebei Medical Journal
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