合成纳米纤维支架水凝胶对周围神经损伤的修复作用

Peripheral nerve regeneration in response to synthesized nanofiber scaffold hydrogel

目的探讨纳米短肽RADA16在大鼠周围神经损伤的再生作用。方法制作坐骨神经损伤的雌性SD大鼠钳夹模型和切断模型,将50只雌性SD大鼠分为假手术组、切断实验组、切断空白对照组、钳夹实验组及钳夹空白对照组5组,每组10只。记录大鼠术后30d坐骨神经传导速度。结果钳夹实验组神经传导速度较钳夹空白对照组快,差异有统计学意义(P<0.05);切断实验组与切断空白对照组差异无统计学意义(P>0.05)。结论自组装肽可促进大鼠坐骨神经的再生和修复。

Objective To investigate the role of RADA16- I in the regeneration of peripheral nerve injury in rats. Methods The clamp models and cut-off models of female Sprague-Dawley rats were established, and the rats were randomly divided into sham-operation group, experimental clamp group, clamp blank control group, experimental cut-off group and cut-off blank control group. The conduction velocity of sciatic nerve in each group was recorded. Results The conduction velocity of sciatic nerve in experimental clamp group was more rapid than that of clamp blank control group （ P 〈 0.05 ）, but there was no significant difference between experimental cut-off group and cut-off blank control group （ P 〉 0. 05）. Conclusion The self-assembling peptide plays an effective role in the regeneration of sciatic nerve in rats.