柯萨奇B组病毒所致面神经麻痹及神经系统病变

AN INQUIRY INTO FACIAL NERVE PARALYSIS AND PATHOLOGIC CHANGES OF THE NERVOUS SYSTEM BY COXSACKIE B VIRUS(CBV)

目的：报道５１例由柯萨奇Ｂ组病毒（ＣＯＸＳＡＣＫＩＲＥＢＶＩＲＵＳＣＢＶ）所致面神经麻痹及神经系统病变；方法：采用酶联免疫吸附试验（ＥＬＩＳＡ）技术。静脉取血１ｍｌ分离血清，检查血清中的ＣＢＶ抗体Ⅰ～Ⅵ型；结果：病毒性脑膜炎２９例，面神经麻痹８例，双肢或四肢肌无力８例，癫痫４例，带状疱疹２例。最小年龄３岁，最大年龄７２岁。临床均给予抗病毒治疗，效果显著；结论：人是柯萨奇病毒唯一的天然宿主，接触是其重要的感染方式，柯萨奇Ｂ组病毒不但能致其它脏器病变，也能致神经系统病变。临床对可疑患者选择ＣＢＶ特异性抗体检查。

Objective:This article reports 51 cases in which facial nerve paralysis and pathologic changes of the nervous system were caused by Coxsackie B virus(CBV).Methods:ELISA was employed.Serum was separated from a vein and CBV antibody Ⅰ～Ⅵ in the serum was detected. Results:Viral meningitis 29 cases;facial nerve paralysis muscle weakness in two limbs or four 8 cases;epilepsy 4 cases;zoster 2 cases;the youngest patient,3 years of age;the oldest patient,72 years of age; All patients were clinically given antiviral treatment,which resulted in remarkable effcets.Conclusion:Men are the sole natural hosts of Coxsackie B virus and contct is the major infecting way.Coxsackie B virus is able to make both visera and nervous system develop pathologic changes.Clinically the suspected patients may be given CBV special viral antibody detection,which is a simpler,faster and more reliable diagnostic method.