克拉霉素与奥美拉唑联合治疗幽门螺杆菌感染的临床疗效观察

CLINICAL OBSERVATION OF CLOTRIMAZDE COMBINED AOMELOZE IN TREATING HP INFECTION

目的：观察克拉霉毒与奥美拉唑联合治疗幽门螺杆菌（ＨＰ）感染的消化性溃疡及慢性胃炎的疗效；方法：８４例病人（男性５４例，女性３０例，年龄４０±１５ａ，均分Ⅲ组：Ⅰ组克拉霉毒０．２５，ｐｏ，ｂｉｄ×７ｄ；Ⅱ组奥美拉唑２０ｍｇ，ｐｏ，ｂｉｄ×７ｄ；Ⅲ组（联合药物治疗组）克拉霉素０．２５，ｐｏ，ｂｉｄ×７ｄ，同时ｐｏ克拉霉素０．２５，ｂｉｄ×７ｄ；结果：溃疡愈合率３组分别为：７１％、７６％、９４％、Ｐ＞０．０５；对慢性胃炎的有效率，分别为６４％、７３％和９１％。Ｐ＞０．０５；对ＨＰ根除率，分别为３２％、３９％和８３％，Ｐ＜０．０１；结论：联合用药对消化性溃疡及慢性胃炎的疗效与单独用药相比无明显差异，但对ＨＰ的根除则联合用药更为明显。

Objective:To evaluate the effect of clotrimazde combined Aomeloze on peptic ulcer and chronic gastitis reculted from Hp.Methods:In three separate studies among 84 cases (Male 54,Female 30.age 40±15a),We tested for 0.25 clotrimazde,P.O.bid×7d;20mg aomeloze P.O.bid×7d and 0.25 clotrimade PO.bid×7d combined aomeloze P.O.bid×7d. Results:The sensitirty of peptic ulcer is 71%,76%,94%.respectively.(P>0.05)The effective rate of chronic gastitis is 64%,73%,91%respectively.(P>0.05).The eradication rate of HP is 32%,39%,83% respectively.(P<0.01).Conclusion:There is no significant difference between separate treatment and combined to peptic ulcer and chronic gastitis.while ,Combined treatmant is more effective on HP during a week.