摘要
定量观察了出生后13个月的先天缺失SOD1基因小鼠的耳蜗毛细胞以及螺旋神经节和疆孔内的神经纤维,并与同龄野生型和出生后2个月的野生型小鼠进行了比较。发现毛细胞和螺旋神经节的缺损约为50%,神经纤维的减少则超过50%。
The hair cells,spiral ganglions and nerve fibers in the cochlea were observed in 13
months old knockout mice lacking SOD1gene,which were compared with the same aged wild
type mice and 2 months old wild type mice.It was found that the hair cells and gaglion neurons
were missing 50%,and the nerve fibers were missing more than 50%in lacking SOD1 gene mice.
This suggests that the serious damage in both hair cells and nerve system in the cochlea
caused by lacking superoxide dismutase combined by copper and zinc.
关键词
毛细胞
神经纤维
螺旋神经节
SOD基因
耳蜗损伤
Free
radicals
Superoxide dismutase
Hair cells
Nerve fiber
Spiral ganglion cell