妇科恶性肿瘤组织诱导血管形成与临床预后因素的相关性

The relationship between experimental angiogenesis induced by human tissues from gynecologic malignancies and clinical prognostic factors

目的探讨妇科恶性肿瘤组织诱导兔角膜血管形成分级可否作为判断患者预后的一项监测指标，并对妇科三种恶性肿瘤之间的生物学行为进行评价。方法分析１１例卵巢恶性肿瘤，１０例乳腺癌，９例子宫内膜癌诱导兔角膜血管形成分级与临床预后因素之间的关系，并对三种恶性肿瘤诱导兔角膜血管生成活性进行比较。结果Ⅱ级血管形成在临床Ⅱ～Ⅳ期，淋巴结阳性或有转移灶的病例明显高于临床Ⅰ期，淋巴结阴性或无转移灶的病例，差异有极显著性（Ｐ＜０．０１）。血管形成分级与组织学分级及肿瘤直径之间差异无显著性（Ｐ＞０．０５）。血管形成活性卵巢恶性肿瘤为“＋＋＋”，乳腺癌和子宫内膜癌分别为“＋＋”。结论瘤组织诱导兔角膜血管形成分级可作为判断肿瘤患者预后指标之一。血管形成活性在这三种恶性肿瘤排列顺序与他们的生物学行为相一致，其预后卵巢恶性肿瘤最差。

bjectives To investigate if the grade of angiogenesis on rabbit's corneas induced by tumor tissues from patients with gynecologic malignant tumors could be one of prognostic indicators in the patients and to valuate the biological behavior of breast cancer, ovarian malignant tumor and endometrial cancer. Methods The grade of angiogenesis on rabbit's corneas induced by malignant tumors (including 10 breast cancers, 11 ovarian malignant tumors and 9 endometiral cancers) were studied in correlation with some clinical factors of prognosis. The activity of angiogenesis on rabbit's corneas induced by these three kinds of tumors were compared. Results Grade angiogenesis were significantly higher in the implanted sites taken tissues from cases of stage IV and lymphnode positive and canceromAuthor etastasis than those with stage I and lymphnode negative and without cancerometastasis (P<0.01). The activity of angiogenesis presented '+++' in ovarian malignant tumor and appeared '++' in breast cancer or endometrial cancer. Conclusions The grade of angiogenesis on rabbit's corneas induced by tumor tissues could be one of prognostic indicators in the patients. The activity of angiogenesis in these three tumors was consistent with their biological behavior and the prognosis of patients with ovarian malignant tumor was the worst.