通心络胶囊治疗皮质下动脉硬化性脑病临床观察

Clinical observation of Tongxinluo capsule on subcortical arteriosclerotic encephalopathy

目的探讨通心络胶囊对皮质下动脉硬化性脑病(SAE)的治疗效果。方法 126例SAE患者随机分为2组,对照组62例,应用阿司匹林肠溶片等常规治疗;治疗组64例,在对照组治疗基础上联合应用通心络胶囊。2组在给药前后采用简易智能量表(MMSE)及社会功能活动调查表(FAQ)观察患者的智能及生活能力,并检测血脂、血小板聚集度、血浆纤维蛋白原及高敏C反应蛋白。结果治疗6个月后,治疗组MMSE及FAQ评分改善明显优于对照组(P<0.05),各实验室检查指标均明显改善且优于对照组(P<0.05),随访期间脑血管事件发生率为9.4%(6/64),显著低于对照组的22.6%(14/62),差异有统计学意义(P<0.01)。结论在常规治疗的基础上加用通心络能进一步改善SAE患者的认知功能和日常生活能力,降低脑血管事件的发生率。

Objective To observe the therapeutic effect of Tongxinluo capsule on subcortical arteriosclerotic encephalopathy（SAE）.Methods Consecutive 126 cases of SAE were randomly divided into control（62 cases） and treatment（64 cases） groups.Control group was given aspirin and conventional treatment,and treatment group was given Tongxinluo capsule based on the conventional therapy.The change in mini mental state examination （MMSE） and functional activities qestionnaire（FAQ） were observed and compared on intellectual and living ability before and after treatment in both two groups,while the indexes of blood lipids,platelet aggregation,plasma fibrinogen and high sensitivity C-reactive protein were detected.Results After 6 months,the FAQ and MMSE scores and the blood parameters in treatmenl group were improved significantly than those in the control group（P0.05）.At the end of follow up period,the cerebral vascular events in treatment group was 9.4%（6/64）,lower than that in the control group 22.6%（14/62,P0.01）.Conclusion Combination Tongxinluo capsule with conventional treatment could further improve the cognitive function and living ability in the patients with SAE,as well as reduce the incidence of cerebrovascular events.