纳米银抗菌水凝胶用于Ⅲ度与Ⅳ度内痔高频电容场痔疮治疗术后的疗效研究

Nanosilver antimicrobe hydrogel in treatment of Ⅲ° and Ⅳ° internal hemorrhoids after high-frequency capacitance pile treatment

目的探讨纳米银抗菌水凝胶在治疗Ⅲ度、Ⅳ度内痔高频电容场痔疮治疗（HCPT）术后疗效的有效性及安全性。方法筛选Ⅲ度、Ⅳ度内痔HCPT术后患者78例，采用随机数字表法将患者分为治疗组与对照组各39例，治疗组于术后第1天至第7天给予纳米银抗菌水凝胶早晚纳肛，1支／次，用药前均用温水清洗患处，对照组术后常规处理，如改善饮食、保持大便通畅、保持肛周清洁、温热坐浴等，不使用纳米银抗菌水凝胶。分别观察患者用药后48h及第7d疼痛、出血、水肿、分泌物、瘙痒等常见症状改善情况，并评价其疗效。结果治疗组48h疼痛、水肿、分泌物3项观察指标评分分别为（0．85±0．74）分、（0．90±0．71）分、（0．95±0．75）分，对照组分别为（2．80±0．41）分、（2．50±0．68）分、（2．25±O．72）分，；治疗组7d水肿、瘙痒2项观察指标评分分别为（0．80±0．77）分、（0．60±0．68）分，对照组分别为（1．70±0．98）分、（1．80±0．95）分，差异均有统计学意义（P〈0．05）。治疗组7d显效15例（38．5％）与对照组[6例（15．4％）]比较，差异有统计学意义（P〈0．05）。结论纳米银抗菌水凝胶可缓解Ⅲ度、Ⅳ度内痔HCPT术后常见不适症状，疗效确切，安全性高。

Objective To evaluate the clinical efficacy and safety of nanosilver antimicrobe hydrogel in the treatment of Ⅲ°, Ⅳ° internal hemorrhoids after high-freauency capacitance pile treatment（HCPT）. Methods Sev- enty-eight patients who received HCPT were randomly divided into study group with Nanosilver Antimicrobe Hydrogel （ n = 39 ） and control group without Nanosilver Antimicrobe Hydrogel （ n = 39）, the symptomatic relief including pain, bleeding, edema, percolate and pruritus was evaluated by scoring system at 48 hours,7d after HCPT. Results Score reduction on pain, edema and percolate [ （0.85 ± 0.74） vs （2.80 ± 0.41 ）, （0.90 ± 0.71 ） vs （ 2.50 ± 0.68 ）, （0.95 ± 0.75） vs （ 2.25 ± 0.72 ） ]was significantly different between the two groups after 48 hours （ P 〈 0.05）. After 7-days treatment, score reduction on edema and pruritus was significantly different that in the study group than in the control group（ P 〈 0.05 ）. But there was no significant difference in score on bleeding between two groups （P 〉 0.05 ）. The effective rat was significantly different between the study group than the control group （P 〈 0.05）. Conclusion Data from the study shows that nanosilver antimicrobe hydrogel is safe and effective in the treatment of Ⅲ°, Ⅳ° internal hemorrhoids after HCPT.