摘要
尽管阿尔茨海默病(AD)早在一个世纪前便已被人类认识,但其病因至今尚未完全阐明。人类遗传学的最新研究显示,3种基因(APP、PSEN1和PSEN2)与早发型家族性AD有关,载脂蛋白E可增加遗传性和散发性AD的风险。本文综述人类基因组研究对AD诊断及预防的影响。
Although Alzheimer＇s disease （AD） has been known for a century, its etiology is still not clear now. The latest progress in human genetics has shown that three genes （APP, PSEN1, PSEN2） are related to early onset familial AD, and apolipoprotein E increases the risk of genetic and sporadic AD. This review focuses on the influence of human genome research on the diagnosis and treatment of AD.
出处
《世界临床药物》
CAS
2010年第7期395-398,共4页
World Clinical Drug
基金
上海市卫生局面上项目(2006052):早期Alzheimer病患者内隐记忆任务的fMRI信号特征与ApoE基因型相关性
关键词
阿尔茨海默病
基因
诊断
治疗
Alzheimer＇s disease
gene
diagnosis
therapy
