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电压门控性钙通道为靶点的镇痛药物研发进展

Voltage-gated calcium channel as a target for new analgesic drugs
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摘要 对慢性非癌性疼痛的治疗目前仍然缺乏理想的镇痛药物,急需开发基于疼痛机制的靶向新型镇痛药物。电压门控性钙通道(VGCC)的改变是疼痛发生的重要分子基础,本文针对N型、T型及α2δ亚基VGCC为作用靶点的新型镇痛药物的研究进展作一综述。 As the treatment o.f chronic noncancer pain lacks effective analgesics at present, it is necessary to develop new analgesics selectively acting on the specific targets. The changes of voltage-gated calcium channels are the important molecule base of pain. This review describes the advances in N-type, T-type and α2δ subgroup calcium channels to be the molecular targets for new analgesic drugs.
作者 王玉梅 夏玉叶 闵旸
机构地区 上海医药工业研究院药理室
出处 《世界临床药物》 CAS 2010年第7期433-437,共5页 World Clinical Drug
基金 国家"重大新药创制"科技重大专项资助(项目编号2009ZX09301-007)
关键词 慢性疼痛 电压门控性钙通道 镇痛药物 chronic pain voltage gated calcium channels analgesic drug
分类号 R971 [医药卫生—药品] R741.05 [医药卫生—神经病学与精神病学]
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参考文献30

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世界临床药物
2010年 第7期

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