皮肤下丘脑-垂体-肾上腺皮质轴与创面愈合

Wound Healing and the Hypothalamo-Pituitary-Adrenal Axis in the Skin

下丘脑-垂体-肾上腺皮质(HPA)轴是机体应激过程中主要的神经-内分泌调节系统之一。皮肤作为人体的最大器官,被证实也具有与中枢HPA轴相似的外周神经-内分泌调节功能。在皮肤组织中,促肾上腺皮质释放激素、促肾上腺皮质释放激素受体和促前阿片黑素细胞皮质激素的基因表达和糖皮质激素均可被检查到。多项实验提示,HPA轴相应的激素在皮肤应急过程中起重要作用,并由此推论其对皮肤损伤、感染或免疫失调所激发的创面愈合过程有调节作用。

The expresses the elements of the hypothalamo-pituitary-adrenal（HPA） axis was one of the main nerve-endocrine regulation systems in the process of physical stress.Kin as the biggest organe,has also been proven to have ragulating function of peripheral nerve-endocine which similar to the HPA.The expression of the elements including corticotrophin releasing hormone,the corticotrophin releasing hormone receptors,pro-opiomelanocortin and glucocorticoids production can be detected.Multiple studies have shown that the expression of the elements of the HPA axis in the skin represents one of the important components of the local response to cutaneous stress.According to these findings,an assumption has been arised that the capability of the elements of the HPA axis expressed by skin may contribute to the wound healing program stimulated by cutaneous stress,such as skin injury,infection,or immune destruction.