期刊文献+

肠道免疫及微环境改变与结直肠癌发生关系的研究进展 被引量:1

Research Progress in the Relationship of Intestinal Immune and Mucosal Micro-environment Immune Changes with Colorectal Cancer
下载PDF
导出
摘要 人体特异性和非特异性免疫改变时,机体的细胞免疫(如淋巴细胞)、体液免疫(如免疫球蛋白和红细胞)、非特异性免疫(如自然杀伤细胞和巨噬细胞)等体系产生紊乱,这些免疫环境的改变可能与结直肠癌发生有一定关系。有研究发现肠微环境(如肠黏膜的SIgA免疫蛋白及肠道菌群)的变化与结直肠癌的发生也有密切联系。 As the specific and non-specific immunity changes,organic disorders appear in the systems of cellular immunity(lymphocytes) ,humoral immunity(immune protein and RBC) ,non-specific immunity (NK cell and macrophage) and these changes of immune environment may be related with colorectal cancer.It has been found that the changes of micro-environment(SigA immunoglobin of intestinal mucus and intestinal bacterial species) also had a close relationship with colorectal cancer.
作者 叶桃 蔡元坤
出处 《医学综述》 2010年第14期2149-2152,共4页 Medical Recapitulate
关键词 结直肠癌 免疫改变 微环境 Colorectal cancer Immune changes Micro-environment
  • 相关文献

参考文献24

  • 1Siegel I,Liu TL,Gleicher N.The red-cell immune system[J].Lancet,1981,2(8246):556-559.
  • 2郭峰.红细胞免疫研究重大进展的回顾与思考[J].深圳中西医结合杂志,1999,9(5):1-2. 被引量:29
  • 3Garratty G.The james blundell award lecture 2007:do we really understand immune red celldestruction?[J].Transfusion Medicine,2008,18(6):321-334.
  • 4薛春燕,高伟,王雅杰,傅强,郭峰,钱宝华.结肠癌患者红细胞与淋巴细胞天然免疫功能变化规律的研究[J].现代肿瘤医学,2007,15(6):817-819. 被引量:4
  • 5Schauenstein E,Rabi H,Steinschiffier W,et al.Selective decrease of serum immunoglobulin G,as a marker of malignant transformation in colorectal tissue[J].Cancer,1997,79(8):1482-1486.
  • 6Albanopoulos K,Armakolas A,Konstadoulakis MM,et al.Prognostic significance of circulating antibodies against carcinoembryonic antigen(anti-CEA) in patients with colon cancer[J].Am J Gastroentrerol,2000,95 (4):1056-1061.
  • 7Muthuswamy R,Urban J,Lee JJ,et al.Ability of mature dendritic cells to interact with regulatory T cells is imprinted during maturation[J].Cancer Res,2008,68(14):5972-5978.
  • 8Van Grevenstein WM,Hofland LJ,Van Rossen ME,et al.Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers[J].Dig Dis Sci,2007,52 (14):2775-2783.
  • 9Berghella AM,Contasta I,Pellegrini P,et al.Are immunological mechanisms involved in colon cancer and are they possible markers for biotherapy improvement?[J].Cancer Biother Radiopharm,2006,21 (5):468-487.
  • 10靳淑黎,李保军,王一平.γ-干扰素对人结肠癌细胞增殖的影响[J].临床内科杂志,2006,23(9):636-637. 被引量:3

二级参考文献45

  • 1王雅杰,薛春燕,花美仙,刘莉,张军,钱宝华,郭峰.恶性肿瘤患者红细胞与淋巴细胞天然免疫功能研究[J].深圳中西医结合杂志,2004,14(5):272-274. 被引量:1
  • 2郭峰.血液免疫反应路线图[J].深圳中西医结合杂志,2005,15(1):1-4. 被引量:40
  • 3李雄彪,崔云龙.益生菌防治肿瘤有实验依据[J].生物技术世界,2005(04M):38-39. 被引量:3
  • 4郭峰,黄盛东,赫丽,李淑德.红细胞在肿瘤免疫反应中的作用[J].中华微生物学和免疫学杂志,1995,15(3):183-187. 被引量:135
  • 5Lee El, Min HY, Chung HJ,et al. A novel adenosine analog, thio-Cl-IB-MECA, induces G0/G1 cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells. Biochem Pharmacol,2005,70:918-924.
  • 6Kabilova TO, Chernolovskaya EL, Vladimirova AV, et all Inhibition of Human Carcinoma and Neuroblastoma Cell Proliferation by Anti-c-myc siRNA. Oligonucleotides. 2006,16 : 15-25.
  • 7Shore GC, Viallet J. Modulating the bcl-2 family of apoptosis suppressors for potential therapeutic benefit in cancer. Hematology ( Am Soc Hematol Educ Program) ,2005,226-30.
  • 8Krajewski S, Blomqvist C,Franssila K, et al. Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res, 1995,55:4471-4478.
  • 9Chami M,Prandini A,Campanella M,et al. Bcl-2 and Bax exert opposing effects on Ca^2+ signaling, which do not depend on their putative pore-forming region. J Biol Chem. 2004,279:54581-54589.
  • 10Maas IW, Boven E, Pinedo HM, et al. The effects of gamma-interferon combined with 5-fluorouracil or 5-fluoro-2 '-deoxyuridine on proliferation and antigen expression in a panel of human colorectal cancer cell lines. Int J Cancer,1991,48,749-756.

共引文献35

同被引文献50

  • 1Bai Y, Xu C, Zou DW, Gao J, Li ZS. Diagnostic accuracyof features predicting lower gastrointestinal malignancy: a colonoscopy database review of 10,603 Chinese patients. Colorectal Dis 2011; 13:658-662 [PMID: 20236151 DOI: 10.1111/ j.1463-1318.2010.02251.x].
  • 2Giorgetti G, Brandimarte G, Fabiocchi F, Ricci S, Flamini P, Sandri G, Trotta MC, Elisei W, Penna A, Lecca PG, Picchio M, Tursi A. Interactions between Innate Immunity, Microbiota, and Probiotics. J Immunol Res 2015; 2015:501361 [PMID: 26090492 DOI: 10.1155/2015/501361].
  • 3Mira-Pascual L, Cabrera-Rubio R, Ocon S, Costales P, Parra A, Suarez A, Moris F, Rodrigo L, Mira A, Collado MC. Microbial mucosal colonic shifts associated with the development of colorectal cancer reveal the presence of different bacterial and archaeal biomarkers. J Gastroenterol 2015; 50: 167-179 [PMID: 24811328 DOI: 10.1007/s00535- 014-0963-x].
  • 4Keku TO, Dulal S, Deveaux A, Jovov B, Hart X. The gastrointestinal microbiota and co!orectal cancer. Am J Physiol Gastrointest Liver Physio12015; 308:G351-G363 [PMID: 25540232 DOI: 10.1152/ ajpgi.00360.2012].
  • 5Zeng H, Lazarova DL, Bordonaro M. Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention. World J Gastrointest Onco12014; 6:41-51 [PMID: 24567795 DOI: 10.4251/wjgo. v6.i2.41].
  • 6Bosscher D, Breynaert A, Pieters L, Hermans N. Food-based strategies to modulate the composition of the intestinal microbiota and their associated health effects. J Physiol Pharmacol 2009;60 Suppl 6:5-11 [PMID: 20224145].
  • 7Gao Z, Guo B, Gao R, Zhu Q, Qin H. Microbiota disbiosis is associated with colorectal cancer. Front Microbiol 2015; 6:20 [PMID: 25699023 DOI: 10.3389/fmicb.2015.00020].
  • 8Ohigashi S, Sudo K, Kobayashi D, Takahashi O, Takahashi T, Asahara T, Nomoto K, Onodera H. Changes of the intestinal microbiota, short chain fatty acids, and fecal pH in patients with colorectal cancer. Dig Dis Sci 2013; 58:1717-1726 [PMID: 23306850 DOI" 10.1007/s10620-012-2526- 4].
  • 9Wu N, Yang X, Zhang R, Li J, Xiao X, Hu Y, Chen Y, Yang F, Lu N, Wang Z, Luan C, Liu Y, Wang B, Xiang C, Wang Y, Zhao F, Gao GF, Wang S, Li L, Zhang H, Zhu B. Dysbiosis signature of fecal microbiota in colorectal cancer patients. Microb Ecol 2013; 66:462-470 [PMID: 23733170 DOI: 10.1007/s00248-013-0245-9].
  • 10Chong ES. A potential role of probiotics in colorectal cancer prevention: review of possible mechanisms of action. World J Microbiol Biotechnol 2014; 30:351-374 [PMID: 24068536 DOI: 10.1007/ s11274-013-1499-6].

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部