子宫内膜增生症的孕激素治疗

Progestin Treatment of Endometrial Hyperplasia

子宫内膜增生症是临床常见的一组病变,为子宫内膜癌的前体。异常阴道出血为子宫内膜增生症的主要症状。基于子宫内膜结构复杂性和细胞异型性的不同程度分为四种类型。在多种治疗方案中孕激素治疗应用最为广泛,且治疗效果明确。针对个体状况的不同,孕激素治疗方案的选择不同。在应用孕激素治疗后,子宫内膜可发生相应的细胞学和组织学的改变。在子宫内膜增生症的病情进展和子宫内膜对孕激素治疗的反应中,多种基因和蛋白质的表达起很重要的作用。

Endometrial hyperplasia is a set of common disease in clinic.It is a precursor lesion of endometrial carcinoma.Abnormal uterine bleeding is the most common presenting symptom of endometrial hyperplasia.It is classified into four types based on varying degrees of architectural complexity and cytologic atypia.The application of progestin treatment is most extensive in many management of endometrial hyperplasia and its therapeutic efficacy is clear.According to the stage of individual,the choice of progestin program is different.There are cytologic and architectural changes that are indicative of a response to progestin treatment.Expression of many genes and proteins on endometrium cells play crucial roles in the progression of endometrial hyperplasia and the responsiveness to progestin of endometrium.