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HLA-G与原因不明复发性流产 被引量：1

HLA-G and Unexplained Recurrent Spontaneous Abortion
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摘要 HLA-G诱导的母胎免疫耐受是保证胎儿免遭母体排斥、妊娠得以顺利进行的关键。HLA-G属非经典HLA-Ⅰ类抗原,可在胎盘绒毛外滋养细胞选择性高表达,主要通过与NK、T细胞表面的杀伤抑制性受体结合,激活胞内免疫受体酪氨酸抑制基序,抑制杀伤及细胞毒活性。滋养细胞HLA-G表达降低或异常表达,影响其与NK、T细胞的结合而阻碍抑制性信号转导,母胎界面出现NK细胞表型以及NK、T细胞功能异常、功能性细胞因子分泌改变等妊娠期免疫紊乱现象,造成母体对胚胎抗原的免疫攻击,导致引发原因不明复发性流产。 Fetal-maternal immunotolerance induced by HLA-G is the pivot factor for successful pregnancy that embryo is not rejected by matrix.Human leucocyte antigen-G （ HLA-G） ,a kind of non-classical HLA-Ⅰ,initially identified as a molecule selectively high expressed on extravillous cytotrophoblasts （ EVCT） ,has been supposed to inhibit the killing activity and cytotoxicity of NK and T lymphocytes through combining with their killing inhibitory receptor and followed by activiating immonoreceptor tyrosine-based inhibitory motif.The decreased and abnormal expression of HLA-G on the surface of trophoblasts impact the combination with NK and T cells,impede the transduction of inhibitory signals.Accordingly,the immonological turbulences such as the phenotypes of NK and the immuno-functions of NK and T cells emerge along with immunological attack on embryo antigens,eventually unexplained recurrent spontaneous abortion is induced.
作者 赵延峰 张宁宁 崔澂
机构地区 华北石油总医院普外科 河北医科大学第四医院妇产科 白求恩军医学院训练部
出处 《医学综述》 2010年第14期2173-2176,共4页 Medical Recapitulate
关键词 人类白细胞抗原G 原因不明复发性流产 免疫耐受 自然杀伤细胞 T细胞 Human leukocyte antigen-G Unexplained recurrent spontaneous abortion Immunotolerance Natural killer cell T cell
分类号 R711.6 [医药卫生—妇产科学]
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参考文献23

  • 1Paul P,Cabestre FA,Ibrahim EC,et al.Identification of HLA-G7as a new splice-variant of the HLA-G mRNA and expression of soluble HLA-G5,-G6,and-G7 transcripts in human transfected cells[J].Hum Immunol,2000,61(11):1138-1149.
  • 2Blaschitz A,Juch H,Volz A,et al.The soluble pool of HLA-G produced by human trophoblast does not include detectable levels of the intron 4-containing HLA-G5 and HLA-G6 isoforms[J].Mol Hum Reprod,2OO5,11(10):699-710.
  • 3彭冰,刘淑芸,邢爱耘,胡敏.人类白细胞抗原G、E在人胎盘组织中的表达及其意义[J].现代妇产科进展,2006,15(7):525-527. 被引量：8
  • 4Clements CS,Kjer-Nielsen L,Kostenko L,et al.Crystal structure of HLA-G:a nonclassical MHC class-Ⅰ molecule expressed at the fetal-maternal interface[J].Proc Natal Acad Sci,2005,102(9):3360-3365.
  • 5Dorling A,Monk NJ,Lechler RI.HLA-G inhibits the transendothelial migration of human NK cells[J].Eur J Immunol,2000,30(2):586-593.
  • 6Van der Meer A,Lukassen HGM,Van Lierop MJC,et al.Membrane-bound HLA-G activates proliferation and interferon-gamma production by uterine natural killer cells[J].Mol Hum Reprod,2004,10(3):189-195.
  • 7Le Bouteiller P.The role of HLA-G expression in the embryo during implantation[J].Gynecol Obstet Biol Reprod,2004,33(1 Pt2):S9-S12.
  • 8Rabreau M,Rouas-Freiss N,Landi M,et al.HLA-G expression in trophoblast cells is independent of embryonic development[J].Hum Immunol,2000,62(11):1108-1112.
  • 9Emmer PM,Steegers EA,Kerstens HM,et al.Altered phenotype of HLA-G expressing trophoblast and decidual natural killer cells in pathological pregnancies[J].Hum Repred,2002,17(4):1072-1080.
  • 10颜卫华,范丽安,杨珏琴,姚芳娟.HLA-G多态性与原因不明习惯性流产相关性研究[J].中国免疫学杂志,2002,18(2):120-121. 被引量：19

二级参考文献33

  • 1Crisa L,Mcmaster MT, Ishii JK, et al. Identification of a thymic epithelial cell subset sharing expression of the class Ib HLA-G molecule with fetal trophoblasts. J Exp Med, 1997,186:289-298.
  • 2Yang Y, Chu W, Geraghty DE, et al. HLA-G in human mononuclear phagocytes and selective induction by IFN-γ. J Expression, 1996,156:4224-4231.
  • 3Carosella ED, Khalil-Daher I, Dausset J,et al. HLA-G mediates protection from natural killer cytolysis: implications in immune tolerance. Transplant Proc,1999,31:1192-1193.
  • 4Riteau B, Menier C, Khalil-Daher I, et al. HLA-G1 co-expression boosts the HLA class I-mediated NK lysis inhibition. Int Immunol, 2001,13:193-201.
  • 5Riteau B, Rouas-Freiss N, Menier C, et al. HLA-G2,-G3,and -G4 isoforms expressed as nonmature cell surfaces glycoproteins inhibits NK and antigen-specific CTL cytolysis. J Immunol, 2001, 15,166:5018-5026.
  • 6Bainbridge DR, Ellis SA, Sargent IL. HLA-G suppresses proliferation of CD4+ T-lymphocytes. J Reprod Immunol, 2000,48:17-26.
  • 7Kanai T, Fujii T, Unno N, et al. Human leukocyte antigen-G-expressing cells differently modulate the release of cytokines from mononuclear cells present in the decidua versus peripheral blood. Am J Reprod Immunol, 2001,45:94-99.
  • 8Fan L, Zhang X, Xu L, et al. Preliminary study on the expression of HLA-G mRNA in normal placenta and placenta with RSA after immunotherapy. Transplant Proc, 1999,31:1854-1856.
  • 9Emmer PM, Veerhoek M, Nelen WL, et al. Natural killer cell reactivity and HLA-G in recurrent spontaneous abortion. Transplant Proc, 1999,31:1838-1840.
  • 10Rabreau M, Rouas-Freiss N, Landi M, et al. HLA-G expression in trophoblast cells is independent of embryonic development. Hum Immunol, 2000,61:1108-1112.

共引文献62

同被引文献12

  • 1Deschaseaux F, Delgado D, Pistoia V, et al. HLA-G in organ transplantation: towards clinical applications [J]. Cell Mol Life Sci, 2011, 68(3): 397-404.
  • 2Rebmann V, Bartsch D, Wunsch A, et al. Soluble totalhuman leukocyte antigen class I and human leukocyte antigen-G molecules in kidney and kidney/pancreastransplantation [J]. Hum Immunol, 2009, 70 (12) : 995 -999.
  • 3Cecati M, Giannubilo SR, Emanuelli M, et al. HLA-G and pregnancy adverse outcomes [J]. Med Hypotheses, 2011, 76(6): 782-784.
  • 4Rebmann V, Switala M, Eue I, et al. Soluble HLA-G is an independent factor for the prediction of pregnancy outcome after ART: a German multi-centre study [J]. Hum Reprod, 2010, 25(7): 1691-1698.
  • 5Berger DS, Hogge WA, Barmada Comprehensive analysis of HLA-G: MM, et al. implications for recurrent spontaneous abortion[J]. Reprod Sci, 2010, 17(4) : 331-338.
  • 6Gonen-Gross T, Goldman-Wohl D, Huppertz B, et al. Inhibitory NK receptor recognition of HLA-G: regulation by contact residues and by cell specific expression at the fetal-maternal interlace [J]. PLoS One, 2010, 5(1): e8941.
  • 7Roussev RG, Coulam CB. HLA-G and its role in implantation [ J ]. J Assist Reprod Genet, 2007, 24 (7) : 288-295.
  • 8Kotze DJ, Hansen P, Keskintepe L, et al. Embryo selection criteria based on morphology VERSUS the expression of a biochemic, al marker (sHLA-G) and a graduated embryo score: prediction of pregnancy outcome[J]. J Assist Reprod Genet, 2010, 27 (6) : 309-316.
  • 9Peng B, Zhang L, Xing AY, et al. The expression of human leukocyte antigen G and E on human first trimester plaeenta and its relationship with recurrent spontaneous abortion[J]. Sichuan Da Xue Xue Bao Yi Xue Ban, 2008, 39(6): 976-979.
  • 10Moser G, Orendi K, Gauster M, et al. The art of identification of extravillous trophoblast [J]. Placenta, 2011. 32(2) : 197-199.

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医学综述
2010年 第14期

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