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The influence of β_2AR polymorphisms as a predictor of successful short acting β_2-agonist nebulization during asthmatic exacerbation

The influence of β_2AR polymorphisms as a predictor of successful short acting β_2-agonist nebulization during asthmatic exacerbation
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摘要 Aim:In this study,we would like to determine associations between β2-Adrenergic Receptor(β2AR)polymorphisms at codon 16 and 27 and the response to short acting β2-agonist during asthmatic exacerbation.Methods:This was a prospective cross-sectional study of one year duration.One hundred and thirty two asthmatic patients were recruited.Five mls of venous blood was taken for DNA extraction and then genotyped for the β2AR polymorphisms using multiplex PCR.Patient's clinical responses to β2-agonist nebulization were then compared to their genotype to determine the association.Results:We found that there was no association between β2AR polymorphisms at both codon 16 and 27 with response towards short acting β2-agonist,P=0.315 and P=0.706 respectively.Conclusion:We suggested that β2AR polymorphisms at both codon 16 and 27 had no influent on the response to short acting β2-agonist. Aim：In this study,we would like to determine associations between β2-Adrenergic Receptor（β2AR）polymorphisms at codon 16 and 27 and the response to short acting β2-agonist during asthmatic exacerbation.Methods：This was a prospective cross-sectional study of one year duration.One hundred and thirty two asthmatic patients were recruited.Five mls of venous blood was taken for DNA extraction and then genotyped for the β2AR polymorphisms using multiplex PCR.Patient＇s clinical responses to β2-agonist nebulization were then compared to their genotype to determine the association.Results：We found that there was no association between β2AR polymorphisms at both codon 16 and 27 with response towards short acting β2-agonist,P=0.315 and P=0.706 respectively.Conclusion：We suggested that β2AR polymorphisms at both codon 16 and 27 had no influent on the response to short acting β2-agonist.
作者 Nasir M Nor Hidayah AB Rashidi A Rusli I
机构地区 Department of Emergency Medicine Department of Pathology Pharmacogenetics Research Group
出处 《海南医学院学报》 CAS 2010年第7期842-846,共5页 Journal of Hainan Medical University
基金 This project was carried out under the financial support of USM short-term grant(304/PPSP/6131324)
关键词 曲马多 镇痛效果 剂量 治疗方法 β2 AR polymorphisms Response Short acting 2 agonist Acute exacerbation of bronchial asthma.
分类号 R614.42 [医药卫生—麻醉学]
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参考文献13

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海南医学院学报
2010年 第7期

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