摘要
目的:测定2型糖尿病早期肾病患者血清胱抑素C水平,探讨其与尿白蛋白排泄率的相关性。方法:收集我院内分泌科住院的2型糖尿病患者45例,其中早期糖尿病肾病组25例,单纯糖尿病组20例,并以30例健康体检者作为对照者组。采用免疫比浊法测定血清胱抑素C水平,放射免疫分析法测定尿白蛋白排泄率。结果:早期糖尿病肾病组及单纯糖尿病组血清胱抑素C水平高于对照组(P<0.01),早期糖尿病肾病组血清胱抑素C水平与单纯糖尿病组比较有统计学差异(P<0.01)。早期糖尿病肾病组血清胱抑素C与尿白蛋白排泄率呈正相关。结论:血清胱抑素C对糖尿病早期肾损伤具有重要的诊断价值。
Objective：To investigate the serum level of cystatin C（CysC） and the relationship between it and urinary albumin excretion（UAE） in patients with early diabetic nephropathy.Methods 25 type 2 diabetes patients with early diabetic nephropathy and 20 type 2 diabetes patients without complication were enrolled.30 health check-up individuals were selected as control group.The level of the serum CysC and UAE is respectively detected by nephelometry and radio-immunity method.Results The levels of the serum CysC in type 2 diabetes patients were significantly higher than those of the control group.There was a significant difference of serum CysC level between early diabetic nephropathy group and simple type 2 diabetes group.The level of Cys C was correlated positively with UAE in patients with early diabetic nephropathy.Conclusion The CysC can be a sensitive marker to reflect the early stage damage in patients with early diabetic nephropathy.
出处
《牡丹江医学院学报》
2010年第3期29-30,共2页
Journal of Mudanjiang Medical University
