摘要
目的:研究nm23-H1、PCNA和CD15在宫颈癌组织中的表达与宫颈癌转移的关系。方法:应用免疫组化SP法检测宫颈癌组织中nm23-H1,PCNA和CD15的表达。结果:在原发性宫颈癌组织中nm23-H1,PCNA和CD15阳性率分别为51.06%、65.96%和51.06%。其中nm23-H1在宫颈鳞状细胞癌中的阳性率43.33%(13/30),在腺癌中的阳性率64.70(11/17)。在鳞癌无宫旁及髂内淋巴结转移中阳性率62.5%(10/16),有转移组阳性率21.42%(3/4),差异有显著性(P<0.001),nm23-H1表达与鳞癌的淋巴结转移呈负相关。在PCNA表达中有淋巴结转移阳性率82.6%(19/23),无转移组54.16%(13/24)(P<0.001),CD15在有淋巴结转移组中阳性表达78.26%(18/23),无转移组25%(6/24),CD15在有无淋巴结转移有显著相关性(P<0.005)。同时低分化癌的阳性率88.88%(8/9)明显高于高分化癌43.75%(7/16),(P<0.001)。结论:nm23-H1,PCNA和CD15的表达对宫颈癌预后评估有一定的临床意义。
Objective：The purpose is to study the expression of nm23-H1,PCNA and CD15 in cervix carcinoma.Methods The expression of nm23-H1,PCNA and CD15 in 47 cases human cervix carcinoma was studied with SP immunohistochemical technique.Results In human cervix carcinoma,the positive expression of nm23-H1,PCNA and CD15 was 51.06%、65.96% and 51.06%.The nm23-H1 in squamous cell carcinoma was 43.33%,adenocarcinoma 64.7%.The positive in squamous cell carcinoma without metastasis of lymph node was 62.5%（10/16）,metustusis of lymph node was 21.4%（3/14）,（p〈0.001）.The nm23-H1 expression level was inversely correlated with lymph node metastasis in squamous cell carcinoma.The positive expression of PCNA in lymph node metastasis was 82.6%（19/23）and non-metastasis was 54.16%（p0.001）.It was 88.88%（8/9） in the low differentiation carcinoma.It was 43.75%（7/16） hight differentiation carcinoma（p〈0.001）.Conclusions：The expression of nm23-H1,PCNA and CD15 may be useful to evaluate the prognosis of cervix carcinoma.
出处
《牡丹江医学院学报》
2010年第3期38-40,共3页
Journal of Mudanjiang Medical University
关键词
宫颈肿瘤
基因表达
免疫组化
预后
cervix neoplasmas
gene expression
immunohistochemistry
prognosis
