ER、PR、Ki-67在绝经后子宫内膜病变中的表达

Expressions of estrogen receptors, progensterone receptors, and Ki-67 in endometrial diseases in post-menopausal women

目的 探讨绝经后子宫内膜息肉的发病机制及与子宫内膜癌的关系.方法 选取我院1998年至2006年手术切取的绝经后子宫内膜标本97例,其中绝经后萎缩的子宫内膜35例,绝经后子宫内膜息肉30例,绝经后子宫内膜癌32例.采用免疫组化法,检测ER、PR、Ki-67在组织中的表达情况.结果 绝经后子宫内膜息肉组ER、PR的表达明显高于萎缩子宫内膜及子宫内膜癌组（P〈0.05）.Ki-67在绝经后萎缩子宫内膜、子宫内膜息肉、子宫内膜癌中的表达逐渐增强（P〈0.05）.结论 （1）雌、孕激素受体含量升高是绝经后子宫内膜息肉发生的主要原因.（2）绝经后子宫内膜息肉中Ki-67的高表达可预测息肉可能发展为癌.

Objective To explore the relationship between endometrial polyps and endometrial carcinoma in postmenopausal woman.Methods 35 samples of atrophic endometrial tissues,30 of endometrial polyps,and 32 of endometrial carcinoma were collected.The expressions of ER,PR,and Ki-67 were detected by immunohistochemical assay.Results The expressions of ER and PR were significantly higher in the polyps tissues than in the atrophic endometrial tissues and the cancerous tissues （P〈0.05）.Ki-67 expression increased gradually in the three different types of tissues （P〈0.05）.Conclusions An elevation in ER and PR plays a major role in the development of postmenopause-induced endometrial polyps.The overexpression of Ki-67 in endometrial polyps may predict of carcinogenesis from polyps.