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表皮生长因子受体（EGFR）基因多态性与非小细胞肺癌中EGFR蛋白表达及淋巴结转移的关系 被引量：1

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摘要 区域淋巴结转移是非小细胞肺癌的主要扩散途径，也是判断肿瘤患者预后的重要因素。表皮生长因子受体（EGFR）是原癌基因c-erbB．1的表达产物，其异常表达和活化在非小细胞肺癌的发生发展中起重要作用，并与肿瘤细胞的生长活跃程度和淋巴结转移密切相关。EGFR第1内含子上存在CA二核苷酸重复序列（CA dinucleotides repeats）多态性，
作者 赵力 江鑫 彭芳 周韧
机构地区 浙江医院病理科 浙江大学医学院病理学与法医学研究所
出处 《中华病理学杂志》 CAS CSCD 北大核心 2010年第7期476-477,共2页 Chinese Journal of Pathology
关键词 表皮生长因子受体 区域淋巴结转移 非小细胞肺癌 基因多态性 EGFR 蛋白表达 C-ERBB 肿瘤患者
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献10

  • 1Berghmans T,Meert AP,Martin B,et al.Prognostic role of epidermal growth factor receptor in stage III nonsmall cell lung cancer.Eur Respir J,2005,25(2).329-335.
  • 2Sueoka-Aragane N,Imai K,Komiya K,et al.Exon 19 of EGFR mutation in relation to the CA-repeat polymorphism in intron 1.Cancer Sci,2008,99(6):1180-1187.
  • 3Mukohara T,Kudoh S,Yamauchi S,et al.Expression of epidermal growth factor receptor (EGFR)and downstream-activated peptides in surgically excised non-small cell lung cancer (NSCLC).Lung Cancer,2003,41(2):123-130.
  • 4Lei W,Mayotte JE,Levitt MA,et al.Enhancement of chemosensitivity and PCD by tyrosine kinase inhibitors correlates with EGFR in NSCLC cells.Anticancer Res,1999,19 (1A):221-228.
  • 5Kris MG,Natale RB,Herbst RS,et al.Efficacy of gefitinib,an inhibitor of the epidermal growth factor receptor tyrosine kinase,in synlptomatic patients with non-small cell lung cancer:a randomized trial.JAMA,2003,290(16):2149-2158.
  • 6Lee DH,Han JY,Lee HG,et al.Gefitinib as a first-line therapy of advanced or metastatic adenoeareinoma of the lung in neversmokers.Clin Cancer Res,2005,11(8):3032-3037.
  • 7van Puijenbroek R,Bosquee L,Meert AP,et al.Gefitinib monotherapy in advanced nommall cell lung cancer:a large Western commuaity implementation study.Eur Respir J,2007,29 (1):128-133.
  • 8Nie Q,Wang Z,Zhang GC,et al.The epidermal growth factor receptor intronl (CA)n microsatellite polymorphism is a potential predictor of treatment outcome in patients with advanced lung cancer treated with Gefitinib.Eur J Pharmacol,2007,570(1/ 3):175-181.
  • 9马飞,徐兵河,林东昕,孙瞳,杨明,刘炬,许建萍,张湘茹,储大同,孙燕.EGFR基因CA-SSR多态与晚期非小细胞肺癌吉非替尼临床疗效的关系[J].中国肿瘤临床与康复,2008,15(1):21-24. 被引量：9
  • 10Dubey S,Stephemon P,Levy DE,et al.EGFR dinucleotide repeat polymorphism as a prognostic indicator in non-small cell lung cancer.J Thorac Oncol,2006,1(5):395-397.

二级参考文献11

  • 1Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer [ J ]. J Clin Oncol, 2003,21:2237-2246.
  • 2Kris MG, Natale RB, Herbst RS, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial[J]. JAMA,2003,290:2149-2158.
  • 3Lee DH, Han JY, Lee HG, et al. Gefitinib as a first-line therapy of advanced or metastatic adenocarcinoma of the lung in neversmokers[ J]. Clin Cancer Res,2005,11:3032-3037.
  • 4van Puijenbroek R, Bosquee L, Meert AP, et al. Gefitinib monotherapy in advanced nonsmall cell lung cancer: a large Western community implementation study [ J ]. Eur Respir J, 2007,29 : 128-133.
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  • 7Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib [ J ]. N Engl J Med, 2004, 350:2129-2139.
  • 8Amador ML, Oppenheimer D, et al. An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors [ J ]. Cancer Res ,2004 ,64 :9139- 9143.
  • 9Etienne-Grimaldi MC, Pereira S, Magne N, et al. Analysis of the dinucleotide repeat polymorphism in the epidermal growth factor receptor (EGFR) gene in head and neck cancer patients [ J ]. Ann Oncol,2005,16:934-941.
  • 10Nie Q, Wang Z, Zhang GC, et al. The epidermal growth factor receptor intron 1 (CA) n microsatellite polymorphism is a potential predictor of treatment outcome in patients with advanced lung cancer treated with Gefitinib [ J ]. Eur J Pharmacol, 2007,570 : 175-181.

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中华病理学杂志
2010年 第7期

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