N末端B型钠尿肽及高敏C反应蛋白对心力衰竭患者的影响

Significances of NT-proBNP and hs-CRP in heart failure

目的 检测心力衰竭的患者中血浆N末端B型钠尿肽（NT-proBNP）和高敏C反应蛋白（hs-CRP）的水平变化,探讨心力衰竭患者血NT-proBNP与hs-CRP的相关性及其在心力衰竭患者预后的临床意义.方法 2009年1至10月随机选择上海交通大学医学院附属仁济医院嘉定分院急诊科100例心力衰竭的患者和与之年龄、性别等相匹配的20名对照者进入本研究.酶联免疫吸附法测定血清NT-proBNP水平,免疫比浊法测定hs-CRP水平.结果 心力衰竭组患者的血NT-proBNP水平均明显高于对照组患者,差异均有统计学意义（均P〈0.01）.心力衰竭患者中血NT-proBNP水平升高程度与同期测定的血hs-CRP水平呈显著正相关.结论 ①血NT-proBNP水平在心力衰竭患者中明显升高,可作为辅助诊断指标之一.②NT-proBNP结合hs-CRP的水平可预测心力衰竭患者的预后.

Objective To detect the level changes of plasma N-terminal B-type natriuretic peptide （NT-proBNP）and hish-sensitivity C-reactive protein（hs-CRP）in patients with heart failure（HF）and explore their clinical correlations and prognostic significances.Methods A total of 100 cases of HF patients were selected along with 20 age and gender-matched controls.The levels of NT-proBNP and hs-CRP were tested.Results The levels of NT-proBNP were significantly higher in HF patients than the controls.And the difference was statistically significant（P〈0.01）.In congestive HF patients,the elevating magnitude of plasma NT-proBNP level showed a significantly positive correlation with that of hs-CRP during the same period.Conclusion ①The level of NT-proBNP is significantly higher in HF patients.And it can be used as one of auxiliary diagnostic indieators.②The level of NT-proBNP in conjunction with hs-CRP can predict the prognosis of HF patients.