摘要
目的观察芒果苷磺酸钠体内外抗白血病的作用。方法采用MTT法,观察不同浓度芒果苷磺酸钠对K562细胞生长的影响;建立小鼠K562白血病模型,考察芒果苷磺酸钠对K562白血病小鼠的生命延长率。结果不同浓度的芒果苷磺酸钠在不同时间对K562细胞均有抑制作用,并随浓度升高和作用时间延长而抑制作用增强,但其抑制作用稍弱于同浓度的芒果苷;芒果苷磺酸钠能明显提高K562白血病小鼠的生命延长率。结论芒果苷磺酸钠有较好的体内外抗白血病作用。
Objective To observe the antileukemia effect of mangiferin sulfonate sodium in vitro and vivo.Methods The effect of different concentrations of mangiferin sulfonate sodium on the proliferation of K562 leukemia cells was examined by MTT assay;and the mouse survival rate was observed by establishing K562 antileukemia model in mice.Results Different concentrations of mangiferin sulfonate sodium inhibited the K562 cell proliferation in different time,the inhibition effect was dependent on time and concentration,but its inhibition effect was slightly weaker than the same concentration mangiferin.Mangiferin sulfonate sodium could obviously prolong mouse survival time.Conclusion Mangiferin sulfonate sodium has good antilelkemia effect in vitro and vivo.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2010年第7期1664-1665,共2页
Lishizhen Medicine and Materia Medica Research
基金
四川省教育厅科研项目(No.2006B027)
广西壮族自治区应用基础专项(No.0731057)
