摘要
肿瘤相关巨噬细胞(TAM)在肿瘤细胞的发生、生长、侵袭和转移方面起到了重要作用,其功能特性类似M2型巨噬细胞。目前多项研究表明TAM与血液系统恶性肿瘤的临床表现及预后相关。基于TAM的促肿瘤作用,目前针对TAM的活化、招募、促血管生成活性、存活及基质重塑等方面设计的靶向治疗药物也进入了基础或临床试验。
Tumor - associated macrophages are playing an important role in the growth, invasion and metastasis of P tumor cells, mimicking M2 type macrophages. Now several studies have indicated that TAM is related to the clinical manifestations and prognosis of hematologic malignancies activation, recruitment, angiogenesis promotion, Based on TAM tumor enhancement, targeted therapy drugs designed against its survival, and matrix remodeling, etc. have come into basic or clinical trials.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第20期2300-2302,共3页
Chinese General Practice
