甘精胰岛素联合赖脯胰岛素治疗初诊2型糖尿病的疗效分析

Effects of Insulin Gargine Combined with Insulin Lispro on the Preliminary Diagnosed Type 2 Dabetes Mellitus

目的探讨甘精胰岛素联合赖脯胰岛素治疗初诊2型糖尿病的临床疗效。方法将30例初诊2型糖尿病患者按随机数字表法分为2组,每组15例。A组给予3餐前皮下注射赖脯胰岛素联合睡前皮下注射甘精胰岛素治疗;B组给予胰岛素泵持续性皮下胰岛素输注治疗。对2组治疗前后空腹血糖、3餐后2 h血糖、3:00血糖、血糖达标时间、日胰岛素用量、低血糖发生率情况进行比较。结果 2组治疗后空腹血糖、3餐后2 h血糖、3:00血糖与治疗前比较差异均有统计学意义(均P<0.05);2组治疗后5个时点血糖控制情况、血糖达标时间、日胰岛素用量及低血糖发生率比较差异均无统计学意义(均P>0.05)。结论与胰岛素泵持续性皮下胰岛素输注治疗相比,甘精胰岛素联合赖脯胰岛素是初诊2型糖尿病患者强化治疗的一种理想方案。

Objective To explore the effects of insulin glargine combined with insulin lispro on the preliminary diagnosed type 2 diabetes mellitus.Methods Thirty patients who were preliminary diagnosed of type 2 diabetes mellitus were divided into two groups by random table method：Group A with subcutaneous injection of insulin lispro before meals and insulin glargine before bedtime,while Group B with continuous subcutaneous insulin infusion by insulin pump.Then the changes of fasting blood sugar,2-hour postprandial blood sugar,3：00 blood sugar compliance time of blood sugar,daily insulin dosage and hypoglycemia situation were observed and analyzed in two groups.Results Both groups significantly reduced fasting blood sugar,2-hour postprandial blood sugar,3：00 blood sugar after treatment（all P0.05）,but there were not significant differences in the control of blood sugar at five time periods after treatment,compliance time of blood sugar,daily insulin dosage and hypoglycemia situation（all P0.05）.Conclusion Compared with continuous subcutaneous insulin infusion by insulin pump,insulin glargine combined with insulin lispro is an ideal treatment method for the preliminary diagnosed type 2 diabetes mellitus.