超敏C反应蛋白与冠状动脉慢血流现象的关系

High-sensitivity C-reactive protein in patients with slow coronary flow

目的探讨血清超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)与冠状动脉慢血流现象(slowcoronary flow,SCF)的关系。方法入选通过TI MI帧计数(thrombolysis in myocardial infarction frame count,TFC)诊断为SCF的病人28例及健康对照组28例,测定其血清hs-CRP水平。线性相关及多元回归分析hs-CRP与SCF的关系。结果 SCF组与对照组在年龄、性别、吸烟、体重指数等基本临床资料上比较具有一致性。SCF组hs-CRP(4.01±1.32 mg/L VS.2.96±1.03 mg/L,P=0.002)水平与对照组比较有统计学差异,hs-CRP(r=0.68,P<0.001)与Mean TFC明显相关。多元回归分析显示hs-CRP(χ2=4.714,β=0.730,P=0.030)是SCF的独立危险因素。结论升高的hs-CRP水平可能参与SCF的形成过程。

Objective To explore the correlation between serum levels of high-sensitivity C-reactive protein（hs-CRP） and slow coronary flow（SCF）.Methods 28 patients（64.3±9.0 years）with documented slow coronary flow,and 28 patients（61.8±12.7 years）with normal coronary flow,defined by TIMI frame count（TFC）,were recruited into our study.Serum levels of hs-CRP were measured in all subjects.Linear correlation and multiple regression analysis were performed for statistical analysis to establish the correlation between hs-CRP and SCF.Results There was no statistical significance between SCF group and control group with regard to age,sex,smoking,body mass index and other baseline data.The levels of hs-CRP（4.01±1.32 mg/L VS.2.96±1.03 mg/L,P=0.002） of slow coronary flow patients was significantly higher than that of control group.TFC was correlated with hs-CRP（r=0.68,P〈0.001）.Multiple regression analysis showed that hs-CRP（χ^2=4.714,β=0.730,P=0.030）was an independent predictor of SCF.ConclusionsThese findings suggest that hs-CRP,which reflects inflammation,may be involved in the pathogenesis of the slow coronary flow.