综合干预对HIV/AIDS孕妇母婴传播阻断的效果分析

An analysis on the effect of comprehensive intervention in maternal-infant transmission block of HIV/AIDS pregnant women

目的探讨阻断艾滋病病毒(HIV)/艾滋病(AIDS)孕妇母婴传播的有效方法。方法对54例要求生育的HIV/AIDS孕妇采取于孕期三联抗病毒治疗,结合选择性剖腹产及人工喂养,新生儿12h内服用齐多夫定口服液等措施,监测孕妇的病毒载量(HIV-RNA)、CD4^+T淋巴细胞数(CD4^+)以及婴儿1、4月龄的HIV-DNA,1岁6月的HIV抗体。结果 54例孕妇HIV-RNA均显著下降,53例婴儿HIV-DNA为阴性。结论采取综合干预措施进行HIV母婴传播阻断是有效的。

Objective To study the effective methods of maternal-infant transmission block in pregnant women with HIV/AIDS. Methods Fifty-four HIV/AIDS pregnant women who had birth demand received triad antiviral therapy during pregnancy and selective caesarean birth as well as artificial feeding of the infant. And the infants were required to take zidovudine oral liquid within 12 hours. Monitoring of HIV-RNA and CD4^＋ T lymphocyte of the pregnant women and HIV-RNA of the infants at the age of 1 month and 4 months as well as HIV antibody of infants at the age of 1.5 years was also required. Results HIV-RNA in 54 pregnant women dropped obviously after therapy, and HIV-DNA in 53 infants appeared negative. Conclusion Taking comprehensive intervention measures is effective in HIV/AIDS pregnant women maternal-infant transmission block.