肾综合征出血热患者可溶性细胞间黏附分子的动态变化

Dynamic changes of sICAM-1 in patients suffering from hemorrhage fever with renal syndrome

目的 观察肾综合征出血热（HFRS）患者可溶性细胞间黏附分子（sICAM-1）的动态变化,探讨其在发病机制中的作用.方法 2006-2007年,在齐齐哈尔市财贸职工医院选择30例HFRS患者作为病例组,选择20例健康献血者为对照组,采集静脉血,采用双抗体夹心ELISA法检测血清sICAM-1的水平,并检测尿素氮水平.结果 HFRS患者血清sICAM-1水平在发病早期、极期、恢复期分别为（47.56±6.51）、（94.23±15.36）、（54.19±8.42）ng/L,尿素氮水平分别为（5.16±0.12）、（33.84±9.24）、（8.20±1.30）mmol/L 对照组sICAM-1水平为（22.63±3.40）ng/L,尿素氮水平为（4.20±0.56）mmol/L.上述两指标的任意两组组间比较,差异均有统计学意义（P均〈0.01）.结论 sICAM-1作为保护因素参与HFRS的发病,细胞免疫在HFRS发病机制中占有重要地位.

Objective To study the dynamic changes of soluble intracellular adhesion molecule-1 （sICAM-1）, and to assess its role in the pathogenesis of hemorrhagic fever（HFRS） with renal syndrome. Methods A total of 30 patients with HFRS（case group） and 20 healthy subjects （control group） from Worker Hospital of Finance ＆ Commerce of Qiqihar city were included in the study during 2006 - 2007. Double-antibody sandwich ELISA method was used to measure the level of sICAM-1 in serum samples. Results The serum levels of sICAM-1 in patients with HFRS in early stage, critical stage, convalescent stage were（47.56±6.51）, （94.23±15.36）, （54.19±8.42）ng/L,respectively. The serum level of sICAM-1 in control group was （22.63±3.40）ng/L. The above values were compared between any two groups, differences were statistically significant （all P 〈 0.01）. The serum level of urea nitrogen in patients with HFRS in early stage, critical stage, convalescent stage were （5.16±0.12）, （33.84±9.24）,（8.20±1.30）mmol/L, respectively. The serum level of urea nitrogen in control group was （4.20±0.56）mmol/L.The above value were compared between any two groups, the differences were statistically significant （all P〈 0.01）. Conclusions sICAM-1 is involved in the pathogenesis of HFRS as protective factors. Cellular immune playes an important role in the pathogenesis of HFRS.