胱抑素C和β_2-微球蛋白在糖尿病肾病早期诊断中的价值

Cysc and β_2-MG for the Early Diagnosis of Diabetic Nephropathy

目的探讨胱抑素C(Cysc)和β2-微球蛋白(β2-MG)在糖尿病肾病(DN)早期诊断中的价值。方法将糖尿病患者按尿蛋白水平分为3组,定量测定各组患者血清中胱抑素C(Cysc)、微球蛋白(β2-MG)、肌酐(Cr)、尿素氮(BUN)的浓度和阳性率,并将结果与正常对照组进行比较。结果 Cysc、β2-MG与Cr、BUN浓度呈正相关,在尿蛋白组病人中,Cysc和β2-MG的阳性率可达80%,而且在糖尿病患者未出现尿蛋白阳性前,Cysc和β2-MG的阳性率较Cr和BUN高,水平变化亦明显,差异有统计学意义(P<0.05)。结论 Cysc和β2-MG对糖尿病肾病的早期诊断较Cr和BUN更有意义,但为提高肾病的阳性检出率,最好进行联合检测。

Objective To explore the early diagnostic value of Cysc and β2-MG detected by immunoturbidimetry in patients with diabetic nephropathy.Methods According to urinary protein level the diabetic patients were divided into three groups.The serum levels of Cysc,β2-MG,Cr and BUN were determined.The concentration and positive rate were compared with the normal control group,and the results were statistically analyzed.Results Cysc,β2-MG,Cr and BUN concentrations were positively correlated.In diabetic patients before the appearance of urinary protein,the Cysc and β2-MG positive rate and the serum levels were higher than the positive rates and levels of Cr and BUN.The Cysc and β2-MG positive rate can up to 80%,with significant difference（P〈0.05）.Conclusions Cysc and β2-MG are more meaningful for the early diagnosis of diabetic nephropathy than Cr and BUN.But to enhance the positive detection rate of kidney disease,it is best to conduct a comprehensive testing.