青蒿素对小鼠无水乙醇型和利血平型胃溃疡的影响

Effects of the artemisinin on gastric ulcer induced by ethanol and reserpine in mice

[目的]探讨青蒿素对无水乙醇型和利血平型小鼠胃溃疡模型溃疡指数的影响.[方法]制作无水乙醇型和利血平型小鼠胃溃疡模型,检测溃疡指数及血清MDA含量.[结果]青蒿素明显降低无水乙醇型和利血平型小鼠胃溃疡模型的溃疡指数及无水乙醇型胃溃疡小鼠血清MDA含量.[结论]青蒿素对由无水乙醇和利血平所致小鼠实验性胃溃疡具有保护作用.

OBJECTIVE To explore the effects of artemisinin on gastric ulcer induced by ethanol and reserpine in mice.METHODS The gastric ulcer models in mice were established by ethanol and reserpine,the index of ulcer and the concents of serum MDA were measured.RESULTS The artemisinin reduced obviously the index of ulcer in the gastric ulcer models induced by ethanol and reserpine,and the concents of serum MDA in the gastric ulcer model induced by ethanol in mice.CONCLUSION The artemisinin has the protective effects for the experimental gastric ulcer induced by ethanol and reserpine in mice.