高血压患者用药依从性与并发症的关系

The Study on the Compliance of Patients with Antihypertensive Therapy and on Compliance Relation to Complication of Hypertension

目的探讨高血压患者用药依从性及依从性与血压控制率、靶器官损伤、并存临床情况的关系。方法 526高血压患者通过问卷调查了解一般情况、用药依从性、分析用药依从性与血压控制和靶器官损伤、并存临床情况的关系。结果常用降压药物的单药应用以钙拮抗剂为最多(60.27%),联合用药中以利尿剂为最多。用一种降压药物者依从性显著高于联合用药者(P<0.05),依从性好的患者血压达标率显著高于依从性差的患者(P<0.05),依从性差的患者靶器官损伤及相关临床情况显著高于依从性好的患者(P<0.05)。结论提高高血压患者的用药依从性可显著提高血压控制率,延缓或减轻靶器官的损伤。

Objective To survey the use of antihypertensive drugs in patients with hypertension and to evaluate the relation between the Compliance in Patients with Antihypertensive Therapy（CPAT） and target organ damage（TOD） ,control rate,association clinical condition（ACC） and compliance. Methods 526 patients with hypertension were interviewed using the questionnaire of compliance.The relation of CPAT and TOD,ACC and the use of antihypertensive drugs were analyzed respectively.Results The five drugs of the most generally used were calcium-channel blocker（60.27%） ,diuretics（42.40%） ,angiotensin-converting enzyme inhibitors（ACEI,24.33%） ,angiotensin II receptor blockade（ARB,20.34%） ,beta-blockers（18.44） ,and compound drugs（13.12%） .The calcium-channel blocker in signal drug treatment was most used,The diuretics in combination drugs treatment was most common.The compliance of taking one kinds of medicine group is better than that of taking over two kinds of medicine group（P〈0.05） .The blood pressure control rate of good CPAT group is better than that of that of bad CAPT group（P〈0.05） .The TOD and ACC in bad CAPT group in remarkably higher than that in good CPAT group（P〈0.05） Conclusion The good CPAT can increase control rate of blood pressure with hypertension and decrease target organ damage remarkably.