换血疗法治疗新生儿败血症

Exchange Transfusion in Septic Neonates

目的:探讨换血疗法对新生儿败血症的疗效。方法:新生儿败血症55例,随机分为同步换血治疗组25例,非换血治疗组30例。比较两组之间的病死率和住院时间、脏器功能受损的程度与病死率间的关系、同步换血组患儿治疗前后血气值及心、肾、生化指标的变化。结果:同步换血治疗组病死率及住院天数均明显低于非换血组(P<0.05)。同步换血后酸中毒得到纠正,PaO2升高,PaCO2下降,同步换血后胆红素明显下降,尿素氮、肌酐明显下降(P<0.05);而同步换血前后电解质、血糖变化不明显(P>0.05)。结论:同步换血疗法对新生儿败血症有较好的疗效。

Objective：To explore the efficacy of exchange transfusion in septic neonate.Method：Fifty-five cases of septic neonates were randomly divided into two groups,25 cases for exchange transfusion group and thirty cases for non-exchange transfusion group.The mortalities,hospital days numbers of dysfunction in single patient were studied.Arterial blood gas,cardiac and renal function were compared before and after transfusion.Result：The mortality and hospital days was less than that of non-exchange transfusion group（P0.05）.Exchange transfusion improved acidosis and respiratory function（PaO2 was increased and PaCO2 was decreased）.Additionally,bilirubin,urea nitrogen and creatinine in serum were significantly decreased（P0.05）.The blood eletrolyte and glucose did not change significantly（P0.05）.Conclusion：The synchronized exchange transfusion as a simple blood prufication method was effective on neonate septicemia.