摘要
以氟苯和正丁酰氯为原料合成了对氟苯丁酮。最佳合成条件为：正丁酰氯与氟苯的摩尔配比是１．４∶１，催化剂无水三氯化铝与氟苯的摩尔比是２．５∶１，溶剂二硫化碳用量为每摩尔氟苯加２５０ｍｌ，反应温度是４５℃，反应时间是６ｈ，对氟苯丁酮的产率高达６８．１％。并用红外光谱和元素分析对其产物结构进行了表征。
The p fluorophenyl propyl ketone was synthesized with fluobenzene (Ⅰ) and butyryl chloride (Ⅱ).Effects of catalyst (Ⅲ,AlCl 3) amount,the solvent (Ⅳ,CS 2) amount,the reaction time,the reaction temperature and the ratio of reactants were investigated.The optimum conditions are follows:a molar ratios of Ⅱ/Ⅰ=1.4/1,Ⅲ/Ⅰ=2.5/1,and a ratio of Ⅳ/Ⅰ=250 ml/molⅠ,reaction temperature is 45℃ and reaction time is 6 hours.The yield under the optimum conditions was up to 68.1%.The product was characterized by IR and elementary analysis.
出处
《精细化工》
EI
CAS
CSCD
北大核心
1999年第1期46-49,共4页
Fine Chemicals
