代谢组学及其在辅助生殖技术中的应用前景

The Prospective of Metabonomics in Assisted Reproductive Technology

提高"试管婴儿"种植率并降低多胎妊娠率是现代辅助生殖技术(ART)的目标。为此,检测和优选配子及胚胎的方法是必不可少的,传统的形态学评估和植入前遗传学诊断技术虽然发挥了重要的作用,但是,现阶段尚缺乏一种客观而精确的评价配子和胚胎的方法。代谢组学是20世纪90年代发展起来的一门新兴学科,是系统生物学的重要组成部分,其精髓是在给定时间和给定条件下定量分析一个生物系统的细胞所有小分子的代谢物质。目前,国外关于代谢组学在辅助生殖技术中应用的报道虽然不多,但应用前景备受关注。

To inerease the efficiency of the IVF procedure by improving implantation rate and lowering the risks of multiple gestations are the primary goals of the current assisted reproduction techology（ART）.These aims require a much improved gamete/embryo testing and selection procedure.Though the current approaches of microscopy-based morphology evaluation and preimplantation genetic diagnosis（PGD） play an impartant role on it,there is lack of an objective and non-invasive techniques to detect and select gamete/embryo at present.Since its birth in the 1990s,metabonomics has become an important part of systems biology.Its essence is the quantitative measurement of all low molecular weight metabolites in an organism＇s cells at a specified time under specific environmental conditions.There are not many reports about metabonomics in ART at present,and this article will be illustrate the prospective of metabonomics in ART.