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胚胎毒性体外试验的研究进展 被引量：7

Review of in Vitro Embryotoxicity Screening Methods
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摘要 胚胎毒性体外试验已广泛应用于胚胎生殖发育毒物筛选和致畸机制研究等方面,现已有三十余种不同类型的毒性测试方法。欧洲替代方法研究中心推荐的有效性较高的3个胚胎毒性体外筛选试验,即体外全胚胎培养试验、胚胎细胞微团培养试验和胚胎干细胞试验具有良好的应用价值,就以上试验的研究方法、应用价值及研究进展综述。 Embryotoxicity tests in vitro,with more than 30 screening methods,are applied on screening embryotoxicity and developmental toxicity widely.Three effectiveness screening tests recommended by the European Center for the Validation of Alternative Methods（ECVAM）showed good value of application,which are whole embryo culture（WEC）、embryonic cell micromass culture（MM）and embryonic stem cell test（EST）.This article reviews recent progress of embryotoxicity testing in vitro.
作者 王雅楠 宋殿荣
机构地区 天津中医药大学 天津中医药大学第二附属医院妇科
出处 《国际生殖健康／计划生育杂志》 CAS 2010年第4期277-280,共4页 Journal of International Reproductive Health/Family Planning
基金 中国博士后科学基金(编号:20080430739)
关键词 胚胎发育 毒性试验 胚胎干细胞 致畸剂 胚胎细胞微团培养试验 体外试验 Embryonic development Toxicity tests Embryonic stem cells Teratogens Limb bud micromass culture In vitro test
分类号 R114 [医药卫生—卫生毒理学]
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参考文献21

  • 1Genschow E,Spielma nn H,Seholz G,et al.The ECVAM international validation study on in vitro embryotoxicity tests:results of the definitive phase and evaluation of prediction models[J].ATLA,2002,30(2):151-176.
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同被引文献100

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二级引证文献18

国际生殖健康／计划生育杂志
2010年 第4期

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