摘要
精子DNA损伤发生的机制包括染色质包装异常、氧化应激和细胞凋亡等。此外,冷冻保存和体外制备技术均能影响精子DNA的完整性。精子DNA损伤与精液参数、精子的受精能力和受精后的胚胎发育潜能、辅助生殖技术(ART)结局及后代遗传风险密切相关。对近年有关精子DNA损伤的机制、冷冻保存和精子制备、精子DNA损伤与精液参数及其与ART结局关系的相关文献进行综述。
It has been demonstated that sperm DNA integrity,mainly caused by oxidative stress,abnormal package of chromatin and abortive apoptosis,have a negative relationship with some semen evaluation parameters such as concentration,motility and morphology,and could affect the potential of fertilization and embryonic development,the outcomes of assisted reproductive technology,and increase the risk of genetic disease for off-spring.Cryopreservation of human spermatozoa and sperm preparation techniques can influence the integrity of sperm DNA.This article briefly reviews the mechanism of sperm DNA damage,cryopreservation,sperm preparation techniques and the relationship of sperm DNA damage and ART.
出处
《国际生殖健康／计划生育杂志》
CAS
2010年第4期285-287,共3页
Journal of International Reproductive Health/Family Planning
关键词
生殖技术
辅助
精子
DNA损伤
精液保存
低温保存
妊娠结局
Reproductive techniques
assisted
Sperm
DNA damage
Semen preservation
Cryopreservation
Pregnancy outcome
