摘要
目的比较安徽省铜陵地区1997年与2007年临床分离常见病原菌对常用抗菌药物耐药状况的变化。方法采用K-B法进行药敏试验,经WHONET5.3软件进行数据分析。结果与1997年相比,2007年金黄色葡萄球菌检出率由11.7%下降至5.5%,MRSA对庆大霉素及红霉素的耐药率分别由30.0%、35.0%上升至85.7%和92.9%,而对磺胺甲噁唑/甲氧苄啶、氯霉素的耐药率却下降;MRCNS对氯霉素的耐药率由69.0%下降至35.3%,2007年发现2株耐万古霉素屎肠球菌;大肠埃希菌、克雷伯菌属检出率增加,对哌拉西林和第二、三代头孢菌素的耐药率明显上升,嗜麦芽寡养单胞菌检出率显著增加,铜绿假单胞菌对头孢他啶及亚胺培南的耐药率分别由6.3%、1.0%上升至18.1%和16.5%,不动杆菌属对庆大霉素的耐药率下降。结论铜陵地区相隔10年病原菌耐药状况有显著变化,病原菌耐药性总体呈增加趋势。
OBJECTIVE To compare the difference of antimicrobial resistance of clinical isolates to antimicrobial agents commonly used in Tongling,Anhui Province 1997 vs 2007.METHODS The disk diffusion method was used to determine the antimicrobial susceptibility.Data were analyzed by WHONET 5.4 software.RESULTS The prevalence of Staphylococcus aureus in 1997 vs 2007 was 5.5% and 11.7%,respectively.The resistance of meticillin-resistant S.aurens(MRSA) to gentamicin and erythromycin was increasing,but decreasing to SMZ-TMP and chloramphenicol.The resistance of meticllin-resistant coagulase negative Staphylococcus(MRCNS) to chloramphenicol was decreasing.Two strains of vancomycin resistant E.faecium were identified in 2007.The prevalence of E.coli and Klebsiella spp.and the resistance to piperacillin and 2nd and 3rd generation cephalosporins was increasing.The prevalence of Stenotrophomonas maltophilia was increasing significantly.The resistance rates of Pseudomonas aeruginosa to ceftazidime and imipenem were increasing significantly.The resistance rates of Acinetobacter spp to gentamicin were decreasing.CONCLUSIONS The bacterial resistance has significantly change in 1997 vs 2007 in Tongling,and is still increasing.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第14期2130-2133,共4页
Chinese Journal of Nosocomiology
关键词
病原菌
耐药性
抗菌药物
药敏试验
Pathogen
Bacterial resistance
Antimicrobial agent
Bacterial susceptibility testing