复方α-酮酸治疗对维持性血液透析患者微炎症的影响

目的观察复方α-酮酸治疗对维持性血液透析患者全身微炎症状态的影响。方法选取36例血液透析患者为研究对象,10例健康志愿者为正常对照,透析患者维持性血液透析(MHD)的同时,予以复方α-酮酸口服,分别于治疗前、治疗后第3、6个月后检测患者血清超敏C反应蛋白(Hs-CRP)和白介素6(IL-6)水平,并比较之间的差异。结果与健康对照者比较,维持性血液透析患者存在全身微炎症状态,血清Hs-CRP和IL-6水平明显升高,经过复方α-酮酸治疗3个月后,Hs-CRP和IL-6水平较治疗前明显下降(P<0.05),随着治疗时间的延长下降更明显。结论复方α-酮酸能减轻维持性血液透析患者的全身微炎症状态。

Objective To explore the influence of treatment of p l usα-ke t o aci d on micro-inflammation state in maintenance hemodialysis patients.Methods 36 stable maintenance hemodialysis patients were enrolled in this study as treated group,and another 10 health volunteers as controls.The level of Hs-CRP and interleukin-6（IL-6） were tested before and 3,6 months after the treatment of plusα-keto acid,compared the difference between them.Results Compared with the controls,high inflammatory state existed on maintenance hemodialysis patients,the level of HsCRP and IL-6 raised significantly.But after 3 months treatment of plusα-keto acid,the level of hs-CRP and IL-6 declined significantly（P0.05）,and the trend was more clearly with treatment time prolonged.Conclusion Plusα-keto acid can attenuate the micro-inflammation state in maintenance hemodialysis patients.