PPARs激动剂延缓动脉粥样硬化的研究进展

Peroxisome proliferators-activated receptor agonists delays the formation of arteriosclerosis

过氧化物酶体增殖物激活受体(PPARs),是配体激活的转录因子,属于核受体超家族成员。PPARs广泛参与机体的脂质代谢、糖代谢、能量代谢、细胞生长分化及生殖过程,并与动脉粥样硬化密切相关,PPARs激动剂参与延缓动脉粥样硬化进程。

Peroxisome proliferators-activated receptors （PPARs） are ligand activated transcriptional factors and belonging to the nuclear receptor superfamily. PPARs play important roles in the regulation of lipid and glucose metabolism, energy homeostasis, cell proliferation, differentiation and reproduction. Furthermore, PPARs agonists were closely correlated to atherosclerosis and involved in delaying the formation of atherosclerosis.