一种间位萜基环己醇的合成新方法

A Novel Synthetic Route to 3-Terpenyl-cyclohexaol

该文设计一条合成间位萜基环己醇化合物的新路线。由氯化苄保护间溴苯酚得到3-溴苯基苄基醚,然后制备成格氏试剂再与环氧蒎烷进行反应,得到的中间体在RaneyNi催化下加氢还原合成目标化合物,3步反应总摩尔收率为44%,产物顺反异构体摩尔比约1∶1.2。这种新的萜基环己醇经过人为感官评定,具有木香,略带花香的檀香香气。

A new synthetic route for 3-terpenylcyclohexanol was designed.3-Terpenylcyclohexanol was synthesized from 3-bromophenol via the protection reaction,the Grignard reaction and hydronation.The total yield of the three steps was 44% and the mole ratio of trans/cis was about 1∶1.2.The product had moody,floral with sandalwood flavor.